Alpha GPC

  • Alpha GPC is an all-natural nootropic that has been shown to:

    • support cognition and mental performance (in a natural and healthy way)
    • promote memory and learning in healthy individuals
    • boost your focus (even in stressful situations) 
      

    Scientific studies show that Alpha GPC is the most efficient dietary supplement to get the powerful molecule choline through your diet, into your blood and brain.

    Once absorbed, it turns into acetylcholine - the learning neurotransmitter - leading to a whole range of cognitive enhancing properties.

      

    Supports Brain Function, Memory and Learning

    The powerful learning neurotransmitter acetylcholine plays a vital role in your memory, nervous system and muscle control.

    Experts agree taking Alpha GPC regularly may boost this neurotransmitter, and:

    • support your brain function
    • promote memory
    • increase alertness (and prevent mental fatigue)
    • boost your levels of focus
      

    It’s a great supplement, backed by science, that may help you take your mental performance to the next level.

      

    Powerful Source Of Nutrients For Brain Health

    Alpha GPC is the only choline source that can easily cross the blood-brain barrier, thereby making it the preferred source of choline for your brain health.

    Our Alpha GPC capsules contain a dose of 325mg compared to only 300 mg per capsule of our competitors, making it the most bioavailable dietary form of choline available on the market.

      

    Natural, Safe, and Effective

    VitaMonk's products are formulated by licensed doctors and manufactured in state-of-the-art facilities following strict GMP compliance standards.

    We go to great lengths to make sure our supplements meet the highest safety standards. When you use our supplements, you KNOW that you’ll only get the highest quality ingredients that have the most scientific backing to help you get results.

      

    We Guarantee Results Or Your Money Back

    We are so confident that you'll love this product, that it comes with a 100% money back guarantee.

    Try it now with NO RISK. If for ANY reason you’re not completely satisfied with this supplement after using it, just let us know.  

    You’ll get 100% of your money back! (No questions asked.) 

    It’s the most effective choline supplement on the market. Try it now RISK FREE and start nutritionally supporting memory and focus to help you through those stressful days where you need to perform.

    *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

  • Directions & Recommended Use:

    As a dietary supplement, take one to two capsules daily or as directed by your health care practitioner.

    Warning:

    Keep out of reach of children.  Do not use if pregnant, nursing, or under the age of 18.  Consult with a heath care professional if you have or suspect a medical condition, or before beginning any new dietary supplement.  If you experience any adverse reactions please discontinue use and contact your heath care professional.



Alpha GPC Choline Overview:

Alpha GPC Choline Overview:

  • Helps improve focus, memory, and cognition
  • Supports healthy cognition, particularly in the elderly
  • Often used as a nootropic
  • Confers neuroprotective traits
  • Enhances power output

Supplementation with choline is beneficial for whole body metabolism and is reported to increase power output. However, it is its cognitive enhancing properties that have made Alpha GPC (Alpha-glycerophosphocholine or α-GPC) of great interest to the world of nootropics.

Typically, 40% of Alpha-GPC’s weight is converted into choline within the body. This makes Alpha-GPC the most bioavailable dietary form of choline available.

In addition to supporting healthy cognition and increasing mental performance, supplementation with Alpha-GPC has been linked with increases in power output, iron absorption, fat oxidation, and iron absorption.

Biological Processes

Choline is involved in numerous biological functions, such as nerve impulse transmission, cell signaling, structural integrity of cell membranes, and lipid transport and metabolism. As it is essential for correct bodily function, choline is commonly referred to as a Pseudovitamin.

Choline undergoes irreversible metabolism into trimethylglycine (TMG) in the mitochondria. This reaction is catalyzed by the enzyme betaine aldehyde dehydrogenase. During neurotransmission, the enzyme choline acetyltransferase converts choline into acetylcholine.

Choline is metabolically interrelated to folate. If there is a shortage of folate in the body then this can be offset by using choline as an alternative methyl donor.

Choline Deficiency

Many people are likely to be at risk of choline deficiency, especially endurance athletes and people who drink excessive amounts of alcohol.

In a study carried out by the Institute of Medicine of the National Academies, ninety percent of Americans were found to have choline intake levels at less than the considered adequate intake (AI: 425g mg/day women; 550 mg/day men)[1].

Choline deficiency can lead to liver damage from a condition known as fatty liver.

Brain Cognition and Memory

Any compound capable of increasing levels of acetylcholine in the brain is known as a cholinergic.

There are two main classes of cholinergics: those that provide the body with choline, such as Alpha-GPC; and those that inhibit acetylcholine breakdown, such as Huperzine-A.

The Most Effective Dietary Cholinergic

Alpha-GPC, an intermediate in lecithin metabolism and a metabolite of phosphatidylcholine (PC), is currently considered the most effective cholinergic. Its consumption results in greater levels of choline in the plasma and brain than seen when taking choline or CDP-choline powder supplements.

Levels of Alpha-GPC uptake in the brain spike between 1 to 3 hours after oral ingestion, with positive influences observed for 24 hours[2].

Increases Dopamine Levels

Dopamine is a neurotransmitter that plays an important role in controlling the brain’s pleasure and reward centers. Interestingly, Alpha-GPC is able to increase the concentration of dopamine in the rat frontal cortex and the cerebellum[3]. This increase is not observed when taking CDP-choline supplementation.

Alpha-GPC is also able to enhance potassium-invoked release of dopamine from neurons[4]. Further to this, following the ingestion of Alpha-GPC rats were found to have increased concentrations of the neurotransmitter serotonin in the same parts of the brain previously mentioned.

Alpha-GPC Confers Neuroprotective Traits

As an efficient prodrug, Alpha GPC is able to confer dietary choline to the body when taken orally. 

It is very likely that Alpha-GPC confers neuroprotective traits. It is thought to do this by increasing brain acetylcholine levels in the frontal cortex and through facilitating high-affinity uptake of choline at the hippocampus[3].

There is also a reported increase in the secondary release of GABA at Alpha-1 adrenergic receptors[5]. GABA, alongside glutamate, plays a major role in the mediation of brain activity.

Increases Focus under Stressful Conditions

Alpha-GPC is able to enhance a person’s ability to focus and pay better attention to detail under stressful conditions when it is consumed alongside phosphatidylserine and caffeine[6].

Promotes Memory Formation and Recall

Alpha-GPC is able to promote memory formation effects through translocation of Protein kinase C (PKC) in the cortex of rats. Furthermore, passive and active learning abilities were found to be enhanced in healthy rats[7].

Alpha-GPC may help to support cognitive function and the formation of memories. The levels of these improvements are likely to be greater than what is reported to when supplementing with CDP-choline.

Improvements in memory formation, retention, and focus allow one’s brain to improve its problem-solving abilities and to recall memories at a much greater pace. Thus Alpha-GPC has many potential mental health performance benefits in healthy individuals.

Improves Power Output and Amplifies Growth Hormone Secretion

Alpha-GPC supplementation (600 mg dose) has been reported to improve power output by up to 14% in power tests involving bench throws [8].

There is also an amplification of growth hormone secretion when taking Alpha-GPC. These enhancements are increased when Alpha-GPC is taken alongside Growth hormone–releasing hormone (GHRH; Somatoliberin).

There is greater stimulation of growth hormone secretion in younger people than is seen in the elderly, but as older people naturally have lower output levels of growth hormones to begin with, there is a much greater relative increase in their growth hormone levels.

Taking Alpha-GPC 45 minutes before exercise may lead to an increase in growth hormone levels during exercise, these increased levels are likely retained for a short period following the experimental exercise period, with levels becoming normalized to standard levels after a while.

Increases in Brain Phospholipid Synthesis and Enhanced Iron Absorption

Choline is a prodrug of Uridine (also available from VitaMonk). Uridine monophosphate nucleotide is able to increase levels of phospholipid synthesis in the brain, which in turn can lead to a greater concentration of glycerophosphocholine levels in adults.

Alpha-GPC has also been linked with facilitating absorption of non-heme iron from foods, doing so with a comparable potency to Vitamin C.

Take With: It is recommended that choline supplements be taken alongside Vitamin B2 (Riboflavin) products as this can mask the fishy smell that is sometimes prevalent when people take choline supplementation.

References

[1] LINUS PAULING INSTITUTE: Micronutrient Information Center [http://lpi.oregonstate.edu/mic/other-nutrients/choline]

[2] Zeisel and da Costa. Choline: An Essential Nutrient for Public Health. Nutr Rev. 2009 Nov; 67(11): 615–623. doi: 10.1111/j.1753-4887.2009.00246.x

[3] Tayebati et al. Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):94-103.

[4] Lopez et al. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav. 1991 Aug;39(4):835-40.

[5] Ferraro et al. Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by alpha-glycerylphosphorylcholine. Neurochem Res. 1996 May;21(5):547-52.

[6] Hoffman et al. The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. J Int Soc Sports Nutr. 2010 Dec 15;7:39. doi: 10.1186/1550-2783-7-39

[7] Govoni et al. PKC translocation in rat brain cortex is promoted in vivo and in vitro by alpha-glycerylphosphorylcholine, a cognition-enhancing drug. Ann N Y Acad Sci. 1993 Sep 24;695:307-10.

[8] Ziegenfuss et al. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Journal of the International Society of Sports Nutrition 20085(Suppl 1):P15 DOI: 10.1186/1550-2783-5-S1-P15

Further Citations Related to Alpha GPC

  • Bellar et al. The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength.  J Int Soc Sports Nutr. 2015 Nov 17;12:42. doi: 10.1186/s12970-015-0103-x. 
  • Kidd PM. Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Altern Med Rev. 2005 Dec;10(4):268-93.

Frequently Asked Questions

What is the Dosage of Alpha GPC VitaMonk

Each VitaMonk Alpha GPC capsule provides 325 mg of L-alpha glycerophosphocholine. We prefer easy to swallow capsules instead of more difficult tablets or bulk powders. All of our products also use vegicaps, so they are vegetarian and gluten free.

Can you take Alpha GPC with food?

Yes, you can take it with or without food.

What are some of the reasons people take Alpha GPC?

There is a myriad of reasons, and several different use cases in which someone might take Alpha-GPC. Here is a list of some of the more common uses based on anecdotal evidence:

  • Enhance focus and concentration
  • To maintain high choline levels when taking a racetam (aniracetam, piracetam, oxiracetam, pramiracetam)
  • Help you relax
  • Improves sleep
  • For energy
  • Weight loss
  • Improves libido
  • For studying
  • For strength

How long does it take to work?

Alpha GPC really isn't meant to be a "quick fix" product. However, it is absorbed quickly, and its positive benefits start kicking in within a short amount of time. 

What is it commonly taken with?

There are a bunch of different possibilities, and many individuals have their own stacks that work best for them. You should always talk to your doctor first about this, but here are a few of the more common combinations frequently mentioned on Reddit, Examine and WebMD.

  • With Omega 3
    • Fish Oil
    • Krill oil
  • With the Racetams
  • Aniracetam
  • Piracetam
  • Oxiracetam
  • Pramiracetam 
  • With Uridine
  • With Noopept
  • Inositol
  • Citicoline
  • ALCAR (Acetyl L Carnitine)

Alpha GPC vs:

  • vs choline
    • it is a superior form of absorbable choline
  • vs DMAE
  • vs ALCAR (Acetyl-L-Carnitine)
  • vs Modafinil
    • Modafinil is a prescription drug designed to treat narcolepsy vs a natural choline source.
  • vs Adderall and Ritalin
    • These are prescription drugs for ADD and ADHD. Alpha GPC is by no means as potent as these: It can stack well with other brain enhancers though.
  • vs CDP choline (cytidine 5′-diphosphocholine or citicoline)
  • vs huperzine A
  • vs Choline Bitartrate
    • The bitartrate is an inferior form of choline and does not have the same nootropic brain boosting benefits
  • vs eggs
    • eggs are great, but it would take A LOT of eggs to get the same amount of choline as a supplement.

How Much Alpha GPC Should I Take Daily?

  • We must always say to take the recommended dose suggested by your doctor. With that said people usually take between 300 mg to 1200 mg per day.
  • How much should I take with…
    • with Aniracetam.
      • Between 300mg - 1200mg a day
    • with Piracetam
      • Between 300mg - 1200mg a day
    • with Noopept
      • Between 300mg - 1200mg a day
    • with Pramiracetam
      • Between 300mg - 1200mg a day

Where to buy Alpha GPC?

You should purchase from VitaMonk of course! We also sell on Amazon with fantastic reviews. You can safely purchase online from us using all major credit cards, Paypal and Bitcoin.

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