Cissus Quadrangularis

  • Cissus Quadrangularis is an all-natural medicinal plant native to Africa and Asia, that’s been used for thousands of years by local tribes for a wide range of beneficial purposes.

    Commonly called the “Bone Setter” this supplement is frequently used by athletes and bodybuilders alike to:

    • Support bone strength & bolster joints
    • Improve (and repair) joint and bone health.
    • REBUILD & promote healthy cartilage
    • Optimize stress and hormones (cortisol & testosterone).
    • Support pain management
     

    Use Cissus Quadrangularis to stay active, move with ease and work out pain free - without your joints and bones killing you!

     

    Supports Healthy Joints, Bones, Tendons, & Ligaments

    Cissus quadrangularis has been shown to support bone strength and bolster joints. It’s often used to support management of joint pain, and is the go-to joint supplement for bodybuilders due to its powerful effects.

    In fact - it’s one of the few compounds that may actually support REBUILDING cartilage and even collagen (a protein that connects cells and tissues to help repair damaged fibers)

    It may even promote bone growth, support healthy bone mass, and support fracture healing in healthy individuals!

     

    Promotes Healthy Hormone Levels To Support Stress and Muscle Growth

    Scientific studies show that cissus quadrangularis is a fantastic optimizer of the hormones cortisol and testosterone for both men and women (as well as the glucose response in healthy individuals).

    Not only can this regulate stress, it can also help you promote management of body fat and support growth of lean muscle mass.

     

    Natural, Safe, and Effective

    Vitamonk's products are manufactured in the USA and formulated by licensed doctors, while following strict GMP compliance standards.

    We go to great lengths to make sure our supplements are 100% safe. When you use our supplements, you KNOW that you’ll only get the highest quality , all-natural ingredients (with no harmful fillers). They’re backed by science, and proven to get you results.

     

    We Guarantee Results Or Your Money Back

    We are so confident that you'll love our product, that it comes with a 100% money back guarantee.

    Try it now with NO RISK. If for ANY reason you’re not completely satisfied with this supplement after using it, just let us know.

    You’ll get 100% of your money back! (No questions asked.)

    *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

     

  • Directions & Recommended Use:

    As a dietary supplement, take two capsules daily or as directed by your health care practitioner.

    Warning:

    Keep out of reach of children.  Do not use if pregnant, nursing, or under the age of 18.  Consult with a heath care professional if you have or suspect a medical condition, or before beginning any new dietary supplement.  If you experience any adverse reactions please discontinue use and contact your heath care professional.



Cissus Overview

Cissus quadrangularis has long been used as an Ayurvedic medicine in the holistic treatment of feminine-related conditions. It has also been traditionally used in the support of bone strength, the healthy rebuilding of cartilage, the maintenance of joints, and for overcoming digestive health issues. Indian women have long used it to help support problems related to the menopause, menstrual cycle, and lack of libido.

Because of its many traditional uses, Cissus has become the focus of much western medical research. Its use seems to be especially popular with athletes and bodybuilders, who believe it may help to support exercise related joint health issues.

The Cissus quadrangularis herb (also known as Asthi Shrinkhala) is a member of the grape family. It is native to the Indian subcontinent, Africa, and SE Asia. The plant is rich in the resveratrol oligostilbene quadrangularin A [1], carotenoids, triterpenoids, ascorbic acid, Friedelin, Vitamins C and E, ketosteroids, δ-amyrone and δ-amyrin. It is therefore likely to enhance antioxidant enzyme activity and to have a role in lipid peroxidation [2].

The Nervous System

  • May have sedative effects

Although popular with athletes because of its support in joint health it seems that this may be a two edged sword as Cissus is associated with sedative effects.

It has been shown to increase the length of diazepam induced sleep and to reduce sleep latency in mice. This finding is thought to be related to enhanced levels of GABAA signaling [3].

  • Impact on power output

The above study also reported that oral supplementation with aqueous Cissus root extract has smooth muscle relaxing properties in mice [3]. These effects were observed after about 30 minutes. It is therefore not recommended to take Cissus before working out.

  • May help with pain

In mice, Cissus has been shown to support analgesic effects associated with the inflammatory response [4]. This research suggested Cissus is involved in the inhibition of arachidonic acid metabolism, a process known to play a role in inflammation [5].

The results of an eight-week preliminary study suggested that in healthy exercise-trained men, daily supplementation of 3,200 mg Cissus quadrangularis might help to reduce joint pain [6].

Bone Mass and Joint Health

In addition to being a mechanism for movement and support, and being involved in the creation of blood cells, the human skeleton acts as a storage reservoir for important minerals.

Bone metabolism itself involves a coordinated removal (bone resorption) and rebuilding (ossification) of bone tissue. This process involves two main cell types: Osteoblasts (involved in the creation of new bone) and osteoclasts (responsible for bone break down).

  • Support of growth factors

It has been reported that regulation of growth factors produced in the bone by osteoblasts is supported by the use of Cissus quadrangularis extract in cell cultures [7]. Further to this, maintenance of rat osteoblast proliferation, mineralization [8], and differentiation of stem cells into osteoblasts was also observed [9]. This support is further enhanced in the presence of estrogen [9].

It also appears that collagen syntheses levels may be enhanced in the osteoblasts [8]. This is likely to support joint health.

Although it has traditionally been used in the treatment of bone fractures, there is presently no evidence that Cissus directly acts in the long-term to set bones in humans. It has however been reported that Cissus may act indirectly to support bone recovery through the regulation of corticosteroid signaling mechanisms and through maintaining bone tissue syntheses [10, 11].

  • Support of healthy bone strength during the menopause

Many experiments have been performed relating to the effect of Cissus quadrangularis and bone loss. When mimicking menopausal effects in rats, an oral intake of 500 mg/Kg of Cissus fully supported healthy bone strength and strongly helped to maintain bone thickness [12].

Both estrogen and Vitamin D are known to play major roles in bone strength and mass. The levels of both were found to be increased in the serum of rats given a Cissus extract supplement. Furthermore, the circulation of estrogen and Vitamin D was supported in the serum [13].

Studies in mice have also demonstrated that supplementation with Cissus is able to support bone mineral density and mass [14].

Support of the Inflammatory Response

Cissus contains many antioxidants and tannin structures. These are thought to be involved in the regulation of macrophages and enzymes, such as COX1 and 2, and 5-LOX, that play important roles in inflammatory responses [15, 16].

Body Weight

  • May support weight loss in obese people

There have been a couple of studies linking the consumption of 300 mg Cissus with weight reduction in obese individuals. This level of supplementation standardizes to 2.5% ketosteroids.

In the first study Cissus supplementation was taken either by itself or in conjunction with Irvingia Gabonensis (African mango seed) supplementation [17] (this supplement has been suggested to support the fat burning process). In both cases significant weight reductions were reported in the experimental group compared to the placebo group. The two supplements were reported to act synergistically.

The second study combined Cissus with a green tea based catechin and vitamin B formulation to investigate weight loss in overweight adult men and women [18]. After an eight-week trial period, there were noticeable reductions in weight reported in those taking the formulation regardless of diet. The formulation was also noted to support healthier cholesterol and fasting blood glucose levels.

Further Reading

  • Reddit:
    • (1) After 18 months using Cissus Quadrangularis here is what I know for sure. {https://www.reddit.com/r/Supplements/comments/38g8e7/after_18_months_using_cissus_quadrangularis_here/}
    • (2) Nootropic Supplement drug recommendations (https://www.reddit.com/r/Nootropics/comments/50dsoo/recommendations_for_general_pain_relief/)
  • Quora: What's the best vitamin for menopausal symptoms? {https://www.quora.com/Whats-the-best-vitamin-for-menopausal-symptoms}
  • WebMD: A look at added Ayurvedic holistic healing natural treatments {http://www.webmd.com/balance/guide/ayurvedic-treatments}
  • Drugs.com: African Mango Uses, Benefits & Dosage | Herbal Database {https://www.drugs.com/npp/african-mango.html }
  • Nature: Compare the anti-obesogenic and antidiabetic effects of plants and mushrooms {http://www.nature.com/nrendo/journal/vaop/ncurrent/abs/nrendo.2016.142.html}

Citations, References, Abstract, and Reviews

[1] Li et al. Total Synthesis of (±)-Quadrangularin A. Angewandte Chemie International Edition. Volume 45, Issue 45, pages 7609–7611, November 20, 2006

[2] Jainu et al. In vitro and In vivo evaluation of free radical scavenging potential of Cissus quadrangularis. African Journal of Biomedical Research. Vol 8, No 2 (2005)

[3] Kumar et al. CNS activity of aqueous extract of root of Cissus quadrangularis Linn. (Vitaceae). Journal of Dietary Supplements. 2010 Mar;7(1):1-8. doi: 10.3109/19390210903534962.

[4] Panthong et al. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. J Ethnopharmacol. 2007 Mar 21;110(2):264-70.

[5] Samuelsson. Arachidonic acid metabolism: role in inflammation. Z Rheumatol. 1991;50 Suppl 1:3-6.

[6] Bloomer et al. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study. Phys Sportsmed. 2013 Sep;41(3):29-35. doi: 10.3810/psm.2013.09.2021.

[7] Muthusami et al. Cissus quadrangularis augments IGF system components in human osteoblast like SaOS-2 cells. Growth Horm IGF Res. 2011 Dec;21(6):343-8. doi: 10.1016/j.ghir.2011.09.002.

[8] Muthusami et al. Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells. J Cell Biochem. 2011 Apr;112(4):1035-45. doi: 10.1002/jcb.23016.

[9] Potu et al. Petroleum ether extract of Cissus quadrangularis (Linn.) enhances bone marrow mesenchymal stem cell proliferation and facilitates osteoblastogenesis. Clinics (Sao Paulo). 2009;64(10):993-8. doi: 10.1590/S1807-59322009001000010.

[10] Chopra et al. Studies of Cissus quadrangularis in experimental fracture repair : a histopathological study. Indian J Med Res. 1976 Sep;64(9):1365-8.

[11] Udupa and Prasad. Cissus quadrangularis in healing of fractures. A clinical study. J Indian Med Assoc. 1962 Jun 1;38:590-3.

[12] Potu et al. Anti-osteoporotic activity of the petroleum ether extract of Cissus quadrangularis Linn. in ovariectomized Wistar rats. Chang Gung Med J. 2010 May-Jun;33(3):252-7.

[13] [Aswar et al. Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats. Indian J Pharmacol. 2012 May;44(3):345-50. doi: 10.4103/0253-7613.96310.

[14] Banu et al. Inhibition of Bone Loss by Cissus quadrangularis in Mice: A Preliminary Report. Journal of Osteoporosis. 2012:101206. Ml doi: 10.1155/2012/101206.

[15] Srisook et al. Anti-inflammatory effect of ethyl acetate extract from Cissus quadrangularis Linn may be involved with induction of heme oxygenase-1 and suppression of NF-κB activation. J Ethnopharmacol. 2011 Feb 16;133(3):1008-14. doi: 10.1016/j.jep.2010.11.029.

[16] Bhujade et al. Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators. J Ethnopharmacol. 2012 Jun 14;141(3):989-96. doi: 10.1016/j.jep.2012.03.044.

[17] [Oben et al. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids in Health and Disease. 2008 Mar 31;7:12. doi: 10.1186/1476-511X-7-12.

[18] Oben et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis. 2006 Sep 2;5:24.

[19] yadav et al. In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Pharmacognosy Res. 2012 Apr;4(2):123-6. doi: 10.4103/0974-8490.94738.

[20] Jainu et al. Cissus quadrangularis L. extract attenuates chronic ulcer by possible involvement of polyamines and proliferating cell nuclear antigen. Pharmacogn Mag. 2010 Jul;6(23):225-33. doi: 10.4103/0973-1296.66941.

[21] Chidambaram and Carani Venkatraman. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet. Food and Chemical Toxicology. 2010 Aug-Sep;48(8-9):2021-9. doi: 10.1016/j.fct.2010.04.044

FAQs

What are some of the commonly used names for Cissus quadrangularis?

It is often referred to as Bone Setter, Devil’s backbone, Pirandai, Adamant creeper, and Hadjobo.

Does Cissus play a role in organs such as the stomach, intestines, and liver

Cissus has been reported to be involved in interactions in the stomach, where it is may have a role in supporting healthy proton pump function [19], and in supporting the stomach lining against ulcer formation [20].

In the liver Cissus supplementation (at very high levels) in the diet of rats has been shown to support against hepatic peroxidation and serum liver enzymes [21].

Is Cissus good for pain in the joints?

It has long been used as a traditional natural treatment for joint and bone health.

Is Super Cissus a wonder supplement?

Many people have mentioned on bodybuilding forums that it has helped them to support joint recovery.

Is Cissus a steroid?

Cissus is a plant. Like all plants it contains plant sterols and stanols (phytosterols). There are also many sterol rich / enriched foods available, such as soybean oil, cereals, and legumes.

Plant sterols may help to maintain cholesterol in a healthy range and so may help maintain a healthy cardiovascular system.

Can I use it pre-workout?

Not recommended, Cissus is thought to have quick-working muscle relaxing properties so it should not be used before working out.

Do Cissus quadrangularis capsules contain vitamin C?

Vitamin C (and E) occurs naturally in the Cissus quadrangularis plant.

What is the recommended dose?

The serving size is two capsules. Please note that the daily value has not yet been established.

What is the dosage of a VitaMonk Cissus capsule?

Each capsule contains 500 mg (0.5 g) of Cissus quadrangularis. There are 120 capsules per product container. Each container contains sixty 1000 mg (one gram) servings. So each order should last for about eight weeks.

Are there any unpleasant Cissus q side effects?

None of the research work performed so far has reported any major side effects in their results. Like with any natural medicinal product it is best to err on the side of caution if you add supplements to your diet. It is worthwhile to consider consulting, and getting advice from, a medical practitioner before use. This is especially the case if you have any pre-existing conditions.

How much Cissus for weight loss?

The best way to lose and maintain a healthy weight is through a healthy diet and a healthy exercise program.

How to take Cissus Powder?

Simply take VitaMonk capsules and tablets; it is much easier than messing around with powders.

Why does Cissus Works?

It contains a multitude of antioxidant and biological active components.

What is Cissus extract used for?

In the support of bone and joint health. It may also be used to help support weight control and it may help in the relief of some menopausal aspects.

Are there any benefits to buying Cissus from you online?

Yes, we are able to offer free shipping on orders over $35. This may help you save money compared to similar products for sale on the high street.

Is your product suitable for vegetarians?

Yes this is a plant-based product and it is enclosed in a VegeCap shell. Our product is made in the USA.

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