Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement
Opti-DHEA™ - Bio-Enhanced DHEA Supplement

Bio-Enhanced DHEA Supplement

DHEA, a hormone naturally produced by your body's adrenal glands, promotes healthy aging


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Most healthy aging enthusiasts already know it: DHEA (or dehydroepiandrosterone) plays an important role in your body. 

DHEA is a hormone that’s naturally produced by your body’s adrenal glands.

Supplementing DHEA can:

  • Act as precursor to both sex hormones - get converted by the body into either testosterone or estrogen (depending on your body’s needs).
  • Maintain healthy bone density, muscle mass and heart health
  • Support healthy aging, brain function and libido
  • Promote hormonal balance in your body

Our OptiDHEA™ is one of the highest quality DHEA supplements (with optimal absorption rate) available on the market.

"I use DHEA to replenish what’s been lost from my natural source and to balance out my cortisol levels. I am a repeat customer to Vitamonk products and can attest to the quality."

- Lydialovesbutterflies (Amazon customer)

60 Day Money-Back Guarantee

We are so confident that you'll love this product that it comes with a 100% money back guarantee. If for any reason you’re not completely satisfied with this supplement after using it, just let us know.


Scientific References & Further Reading

A Look at the Natural Endogenous Steroid Hormone DHEA

  • Is a precursor of the androgens Testosterone and Dihydrotestosterone (DHT)
  • Helps to maintain steroid production in the adrenal glands
  • Supports the immune system
  • Supports healthy aging
  • Supports the menopause
  • Supports sexuality
  • May enhance muscle strength
  • Supports cognition and lifts mood
  • May offer support for healthier bone mass

Dehydroepiandrosterone, commonly known as DHEA, is a steroid hormone that is naturally produced in the adrenal glands, the brain, and the gonads. Other names for DHEA include prasterone, androstenolone, and 3β-Hydroxy-5-Androstene-17-one. 

DHEA is the most abundant circulating steroid in the body and its main role is as a precursor in the production of other steroids, especially testosterone and estrogen. 

As levels of DHEA naturally decline as one ages it is a popular supplement for people over the ages of 40 who wish to support their DHEA pool and the production of DHEA’s downstream targets. It is also often taken at larger doses by younger people who are trying to enhance hormonal levels for muscle mass. 

DHEA is known to have many other biological functions and effects in addition to acting as a precursor for other hormones. It may act independently as a neurosteroid [1], and is able to bind to receptors in the nucleus and at the cell surface [2].

DHEA is not naturally present in foods; your body naturally produces it. Therefore, it may be beneficial to include foods that are rich in its precursor (cholesterol) if you are trying to support DHEA levels and function through diet alone. These include flax seeds, olive oil, and foods rich in omega 3 fatty acids such as fortified eggs, salmon, trout, mackerel, and other fatty fish.

Levels of DHEA peak in the middle of your 20’s and then decline as you age. This age related decline is thought to be associated with numerous medical conditions in unhealthy elderly people [3].

Muscle Mass

In many cases, a 100 to 150 mg supplementation of DHEA may offer support for muscle mass. In young men, taking 100 mg of daily DHEA supplementation while partaking in a mixed exercise regime may result in significantly higher levels of circulating DHEA, this has a positive effect on testosterone levels [4]. The authors of this research work concluded that the use of DHEA-S might therefore offer support in protecting skeletal muscle from damage caused by exercise training.


In experiments performed in rats, oral ingestion of DHEA has been reported to correlate to low overall consumption of food [5], especially of fatty foods [6].

It is thought that DHEA may have a positive impact on the feeling of being full [7]. It is thought that DHEA may support weight control by its own mechanisms as opposed to acting through downstream metabolites such as testosterone. This might be through regulation of proteins involved in sterol element binding and lipid binding [8]. These may affect adiposity via the presence of peroxisome proliferator-activated receptor gamma in adipocytes (fat cells) [8].

Healthy Aging and Heart / Cardiovascular Health

DHEA may have an healthy effect on the size of telomeres at the end of a chromosome [9]. Telomeres are involved in protecting the chromosome from detrimental effects.

DHEA is also thought to have a positive effect on the support of cardiovascular health through the control of lipoprotein levels. This is thought to result from its conversion into estrogens and seems to affect LDL and HDL cholesterol levels to a similar degree [10, 11].

Through its interaction with a steroid-specific G-protein coupled receptor, DHEA may be able to increase levels of cGMP and NO by affecting PI3K/Akt and MAPK cascades [12]. This cellular mechanism may support cardiovascular protective effects.

Support of Mood

DHEA supplementation may act as a neuroendocrine mediator to help support mood. As people age there is a natural decline in the levels of circulating DHEA. 

Oral and topical supplementation increases the amount of circulating DHEA, and may therefore help to boost mood [13], especially in postmenopausal women [14]. The mechanism for the increased feelings of well-being are thought to be due to stimulation of happiness related neurosteroids such as beta-endorphins [15].

Bone Mass

In the long term, the supplementation of DHEA may help to support healthy maintenance of bone mass.

A study using eighty-six men suggested that bone formation and absorption was supported by DHEA [16]. In a one year study (elderly people) aimed at investigating the effects of DHEA supplementation on fat free mass and bone mineral density it was reported that DHEA may help to maintain bone mass at healthier levels in the hips in men and women [17]; this study also reported support of lumbar spine bone mass in women. 

Interactions with hormones

As it is a precursor to many hormones, it is no surprise that DHEA appears to impact and interacts with other hormones. It has been reported to be involved in maintaining cortisol at healthy levels in people with poor moods [18]. Melatonin is just one of many compounds thought to affect the ratio of cortisol to DHEA [19].

When taken prior to exercise, 50 mg of DHEA taken orally was reported to enhance the levels of circulating DHEA-S and free testosterone in ~49 year old males partaking in high-intensity exercises (cycling intervals) [20]. The authors also noted that DHEA helped to maintain these levels during HIIT workouts.                                                    

Citations, Reviews, Reports, and References 

  • [1] Baulieu and Robel. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. PNAS. vol. 95 no. 8 4089–4091
  • [2] Webb et al. The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors. Drug Metabolism Reviews. Volume 38, 2006 - Issue 1-2. http://dx.doi.org/10.1080/03602530600569877 
  • [3] Perrini et al. Associated hormonal declines in aging: DHEAS. J Endocrinol Invest. 2005;28(3 Suppl):85-93. 
  • [4] Liao et al. Effect of dehydroepiandrosterone administration on recovery from mix-type exercise training-induced muscle damage. Eur J Appl Physiol. 2013 Jan;113(1):99-107. doi: 10.1007/s00421-012-2409-6.
  • [5] Richards et al. Long-term oral administration of dehydroepiandrosterone has different effects on energy intake of young lean and obese male Zucker rats when compared to controls of similar metabolic body size. Diabetes Obes Metab. 1999 Jul;1(4):233-9. 
  • [6] Pham et al. The effect of dehydroepiandrosterone on Zucker rats selected for fat food preference. Physiol Behav. 2000 Sep 15;70(5):431-41.
  • [7] Navar et al. Dehydroepiandrosterone (DHEA) blocks the increase in food intake caused by neuropeptide Y (NPY) in the Zucker rat. Nutr Neurosci. 2006 Oct-Dec;9(5-6):225-32.
  • [8] Kajita et al. Dehydroepiandrosterone down-regulates the expression of peroxisome proliferator-activated receptor gamma in adipocytes. Endocrinology. 2003 Jan;144(1):253-9.
  • [9] Vasunilashorn and Cohen. Stress Responsive Biochemical Anabolic/Catabolic Ratio and Telomere Length in Older Adults. Biodemography Soc Biol. 2014; 60(2): 174–184. doi: 10.1080/19485565.2014.950722
  • [10] Nestler et al. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab. 1988 Jan;66(1):57-61.
  • [11] Warner and Gustafsson. DHEA - a precursor of ERβ ligands. J Steroid Biochem Mol Biol. 2015 Jan;145:245-7. doi: 10.1016/j.jsbmb.2014.08.003. Epub 2014 Aug 12.
  • [12] Liu and Dillon. Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor. Steroids. 2004 Apr;69(4):279-89. 
  • [13] Morales et al. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf). 1998 Oct;49(4):421-32.
  • [14] Labrie et al. Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women. J Clin Endocrinol Metab. 1997; 82 (10): 3498-3505. doi: 10.1210/jcem.82.10.4306
  • [15] Bernardi et al. Effect of dehydroepiandrosterone on central and peripheral levels of allopregnanolone and beta-endorphin. Fertility and Sterility. 2005 Apr;83 Suppl 1:1161-8.
  • [16] Nordin et al. The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women. J Clin Endocrinol Metab. 1985 Apr;60(4):651-7.
  • [17] Jankowski et al. Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. J Clin Endocrinol Metab. 2006 Aug;91(8):2986-93
  • [18] Hucklebridge et al. The diurnal patterns of the adrenal steroids cortisol and dehydroepiandrosterone (DHEA) in relation to awakening. Psychoneuroendocrinology. 2005 Jan;30(1):51-7.
  • [19] Pawlikowski et al. Effects of six months melatonin treatment on sleep quality and serum concentrations of estradiol, cortisol, dehydroepiandrosterone sulfate, and somatomedin C in elderly women. Neuro Endocrinol Lett. 2002 Apr;23 Suppl 1:17-9.
  • [20] Liu et al. Effect of acute DHEA administration on free testosterone in middle-aged and young men following high-intensity interval training. Eur J Appl Physiol. 2013 Jul;113(7):1783-92. doi: 10.1007/s00421-013-2607-x
  • [21] Calvo et al. Pangenomic changes induced by DHEA in the skin of postmenopausal women. J Steroid Biochem Mol Biol. 2008 Dec;112(4-5):186-93. doi: 10.1016/j.jsbmb.2008.10.008 
  • [22] Hackbert and Heiman. Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. J Womens Health Gend Based Med. 2002 Mar;11(2):155-62.
  • [23] Barad and Gleicher. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Hum Reprod. 2006 Nov;21(11):2845-9.

Further Reading

  • University of Maryland medical center: How to take DHEA {http://umm.edu/health/medical/altmed/supplement/dehydroepiandrosterone}
  • WebMD: DHEA Supplements for Health conditions and disease, weight loss, mood and depression, and aging {http://www.webmd.com/diet/dhea-supplements#1}
  • Drugs.com : DHEA Side Effects {https://www.drugs.com/sfx/dhea-side-effects.html}
  • Examine: Guide to Dehydroepiandrosterone (https://examine.com/supplements/dehydroepiandrosterone/) 
  • Reddit 1: Bodybuilding and DHEA {https://www.reddit.com/r/Nootropics/comments/ngw6l/what_does_dhea_do_for_you/}
  • Reddit 2: Nootopics: Experience taking Oral DHEA Supplements – weight and power gain, and my improved shape {https://www.reddit.com/r/bodybuilding/comments/2o5n4o/my_experience_with_dhea/} 
  • Wikipedia: Biochemistry and the uses of DHEA {https://en.wikipedia.org/wiki/Dehydroepiandrosterone}

Where are the adrenal glands located?

Above the kidneys.

What is the main function of DHEA?

It acts as precursor to sex hormones such as estrogen and testosterone. It can also act independently to affect other biological functions. 

Does DHEA peak at a certain age?

Yes, you will have maximal amounts of DHEA in your system when you are in your 20’s, the levels will naturally decline as you age.

Does DHEA work as a skin treatment?

Topical application of DHEA has been reported to support healthy aging of skin in post-menopausal women [21]. This may be a result of improved collagen biosynthesis.

Is there a link between DHEA and sexuality?

It has been reported that DHEA may support mental and sexual physical sexual arousal in postmenopausal women [22].

Are there any known side effects associated with DHEA?

As it is a hormone, it is not surprising that there are many potential side effects that can occur. Some of these are as follows: women have reported hair growth in unwanted places, deeper voices, disrupted periods, oily skin, and affects on breast (smaller) and genital size (larger). In men, some side effects reported include breast tenderness, reduced testes size, increased aggression, and the need to urinate. 

Side effect symptoms common to male and females may include acne, nausea, itchy skin, changes in mood such as becoming emotional, difficulty in getting to sleep, and changes in levels of insulin, other hormones, and cholesterol.

As with medicines / medications, drugs, and other supplements it is important to seek a doctor’s advice before taking DHEA. Cease taking it and immediately consult your general healthcare practitioner if you suffer from any kind of side effect.

Is DHEA banned and/or is it illegal?

It is legal in the USA and is not a controlled substance.

DHEA what dosage?

There is currently no RDA for DHEA. It is often taken at doses of 25 to 50 mg by people over the age of 40. Younger people looking to use it to boost testosterone levels and for its benefits regarding muscle strength typically take a higher dose. 

When does DHEA decline?

Naturally high levels decrease from your mid-twenties onwards. 

Where is DHEA converted to testosterone?

Conversion of DHEA into bioactive metabolites occurs in the body. Oral DHEA is first converted into its sulfate form in the liver and intestines by the sulfotransferase SULT2A1. Testosterone itself is largely synthesized in the gonads and the adrenal glands. 

What are its metabolites?

The main metabolites include Androsterone, Etiocholanolone, DHEA sulfate (DHEA-S), Androstenedione, Androstenediol, Testosterone and Androstanediol.

Where is DHEA made in the body, which organ produces it?

This hormone is largely made in the adrenal glands, testes, ovaries, and the brain.

Are there any direct agonists and antagonists functions of DHEA?

Yes, e.g., the estrogen (ER) receptors such as ERbeta. 

What does DHEA do for fertility?

Cohort studies have suggested that DHEA may help to support ovarian function in women who have a diminished ovarian reserve [23].

Is this product suitable for vegetarians?

Yes, our VitaMonk products use Vegicap capsules. Our products are gluten free.

Do you offer free shipping if I buy online?

Yes, on all orders over $35.

Can I shop for your products in other places?

Yes, you can also buy VitaMonk on Amazon.

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