HMB

  • HMB is an advanced metabolite of the the most investigated BCAA Leucine, showing potential in effectively supporting muscle growth and prevention of muscle atrophy in healthy individuals.

     

    Improve Protein Synthesis and Muscle Growth 

    As a leucine metabolite, it may promote variety of benefits from:

    • Support repair of muscle fibers
    • Support a healthy response to age-related muscle atrophy
    • Support preservation muscle gains in athletes on restrictive diets
     

    As a supporting component in muscle cell membranes, HMB is believed to provide a healthy response to muscle catabolism by promoting management of protein breakdown.

    Most exciting is its potential to support muscle retention during periods of accelerated muscle atrophy. Helping athletes preserve muscle mass while on restricted calorie diets and specifically during over-training and over-reaching workout phases.

       

    Natural Way To Build Lean Muscle Mass

    • Naturally occurring metabolite
    • Support lean muscle mass while decreasing fat
     

    Consumed through both plant and animal foods, HMB is well accepted as a natural dietary supplement.

    Studies suggest its ergogenic role and anabolic functions are responsible for its effective support of lean muscle mass while managing fat mass.

     

    Promote Healthy Levels of the Stress Hormone Cortisol

    HMB supports a healthy response to the high levels of the stress hormone cortisol. This can support management of healthy levels of stress. To help you avoid the fat increase that occurs around the belly and waistline commonly associated with stress.

     

    Natural, Safe, and Effective

    VitaMonk's products are formulated by licensed doctors and manufactured in state-of-the-art facilities following strict GMP compliance standards.

    We go to great lengths to make sure our supplements meet the highest safety standards. When you use our supplements, you KNOW that you’ll only get the highest quality ingredients that have the most scientific backing to help you get results.

     

    We Guarantee Results Or Your Money Back

    We know you'll love our product.

    If you don't see sustained or increased gains in your workout we provide a 100% money back guarantee. No questions asked.

    Try our product Risk Free and start supporting your healthy lifestyle today!

    *These statement have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

  • Directions & Recommended Use:

    As a dietary supplement, take two capsules daily or as directed by your health care practitioner.

    Warning:

    Keep out of reach of children.  Do not use if pregnant, nursing, or under the age of 18.  Consult with a heath care professional if you have or suspect a medical condition, or before beginning any new dietary supplement.  If you experience any adverse reactions please discontinue use and contact your heath care professional.

     



    An Overview of HMB (β-Hydroxy β-methylbutyric acid)

    • Supports Power output
    • Helps on the body’s fight against muscle damage
    • Supports a healthy lean body mass
    • May help to prevent exercise-related muscle damage
    • Promotes recovery from exercise

    Beta-Hydroxy beta-methylbutyric acid (acronym HMB; also known as HydroxyMethylButyrate) is is a naturally occurring metabolite involved in the leucine metabolic pathway.

    Leucine (L; Leu) itself is an essential amino acid that cannot be created from scratch by the body. It plays an important role in the biosynthesis of proteins and is a major component of many protein subunits, such as ferritin  (involved in the controlled release of iron) and astacin.

    Leucine is used by the body in large amounts in adipose and muscle tissues, and in the liver. It is also known to be an activator of the kinase mTOR.

    Foods that naturally include high amounts of dietary leucine include Soybeans, Hemp seed, peanuts, beef, pork, chicken, fish, eggs, wheat germ, almonds, and oats.

    The metabolism of around 60% of dietary L-leucine occurs within a few hours, with 40% being converted to acetyl-CoA and from 2 to 10% being converted to HMB.

    Although the body naturally produces HMB from the oxidation of the L-Leucine ketoacid, it is usually taken as a dietary supplement by adult men and women looking to support and maintain muscle strength and lean body mass.

    HMB supports healthy protein production and the maintenance of lean body mass, it is also associated with speeding up recovery from exercise. An adult man of 70 KG naturally produces 0.2 to 0.4 g of HMB per day, whereas the usual normal dosage used to support muscle function and mass by training athletes is around 3 g per day [1].

    The initial research into how HMB affects skeletal muscle in humans was performed by Nissen and colleagues at the Iowa State University when they were investigating how to support wound healing in people suffering from conditions causing muscle wasting [2].

    Support of Healthy Muscles and the Effects of Exercise

    HMB has been reported to facilitate proliferation and differentiation of muscle cells. The peak rates for these HMB mitogenic properties occur at dosages of 50 μg per ml in birds [3].

    HMB has been demonstrated to stimulate the synthesis of protein in the muscles by means of the mTOR (Mechanistic target of rapamycin) pathway [4]. It may also act through an independent mechanism via the Akt signaling pathway.

    It has also been shown to positively influence apoptosis of myocytes and skeletal muscle precursor satellite cells. It is thought to promote the reduction of apoptosis through altering the ratio of Bcl-2::Bcl-X downstream of Akt [3]. This is likely to offer support for healthier muscle cell aging, and to help protect against muscle wasting and breakdown [5, 6].

    There is support that HMB may reduce soreness in muscles, with both free acid and calcium salt forms of HMB thought to be beneficial for muscle recovery in healthy individuals undergoing a weight lifting programs [7]. There is also a mental aspect associated with HMB in that normal untrained people feel they recover quicker following an exercise session [8].

    With regards to protein synthesis in the muscles, HMB is able to effectively support healthy synthesis when taken orally [9].  It is noteworthy that leucine is even more effective.

    It is likely that HMB may act as an agent to promote healthy anti-catabolic effects and therefore plays a role in the preservation of muscle mass. It is thought to do this in a different manner to that observed when taking leucine supplementation [10, 11}. It is also able to support the retention of healthy muscle in people suffering from conditions that lead to muscle loss [12].

    The evidence for affecting power output when taking HMB supplementation is inconclusive. However, there is some support for HMB (3 g) promoting muscle strength over a two-month period in healthy individuals undergoing leg extension training regimes [13].

    Healthy Aging

    Studies in both humans and animals suggest that HMB supports healthy maintenance of lean mass during the aging process.

    It has also been shown to help maintain muscle control and power output in elderly women when given in a combination with Arginine and Lysine with little impact on lean mass [14]. In healthy elders undergoing a weight training regime, HMB was able to support the development of lean mass and to enhance muscle tone over a two-month period, with no associated gain in fat mass [15].

    Healthy Weight Maintenance and Increases in Dietary Consumption

    It has been noted in some investigations that supplementation with HMB may lead to an increase of appetite in trained male athletes [13]. This may prove beneficial for underweight people wishing to support the gain of a more healthy body weight.

    It is thought that HMB may be beneficial in supporting fat mass loss in female athletes who are following a calorie-controlled diet [16].

    Further Reading

    • Reddit: HMB’s role in enhancing strength and power {https://www.reddit.com/r/Fitness/comments/2w6zis/new_study_finds_that_hmb_enhances_hypertrophy}
    • Quora: HMB and creatine for muscular strength, endurance, and bulking {https://www.quora.com/Other-than-creatine+HMB-what-supplements-will-make-your-muscular-strength-endurance-go-up-even-if-muscle-mass-doesnt}
    • Wikipedia: An in-depth look at the amino acid leucine {https://en.wikipedia.org/wiki/Leucine}
    • WebMD: User ratings for HMB use {http://www.webmd.com/vitamins-supplements/ingredientreview-45-HYDROXYMETHYLBUTYRATE+HMB.aspx?drugid=45&drugname=HYDROXYMETHYLBUTYRATE+(HMB)}
    • Drugs. : Guide to sports and dietary supplements {https://www.drugs.com/slideshow/sports-dietary-supplements-1231 }
    • Science Mag (AAAS): Bulking up, No Sweat {http://www.sciencemag.org/news/1997/05/bulking-no-sweat}

    Citations, Reviews, and References

    [1] Molfino et al. Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials. Amino Acids. 2013 Dec;45(6):1273-92. doi: 10.1007/s00726-013-1592-z.

    [2] Nissen and Abumrad. Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB). Nutritional Biochemistry. June 1997Volume 8, Issue 6, Pages 300–311. doi: 10.1016/S0955-2863(97)00048-X

    [3] Peterson et al. In vitro exposure with beta-hydroxy-beta-methylbutyrate enhances chicken macrophage growth and function. Vet Immunol Immunopathol. 1999 Jan 4;67(1):67-78

    [4] Sousa et al. Calcium β-Hydroxy-β-Methylbutyrate: 1. Potential Role as a Phosphate Binder in Uremia: In vitro Study. Nephron 1996;72:391–394

    (DOI:10.1159/000188901)

    [5] Jejurikar et al. Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosis. Exp Gerontol. 2006 Sep;41(9):828-36.

    [6] Aversa et al. β-hydroxy-β-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. International Journal of Oncology. 2011 Mar;38(3):713-20. doi: 10.3892/ijo.2010.885. Epub 2010 Dec 23.

    [7] Nunan et al. Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementation. J Strength Cond Res. 2010 Feb;24(2):531-7. doi: 10.1519/JSC.0b013e3181c4d370 cr

    [8] Hung et al. Effect of β-hydroxy-β-methylbutyrate Supplementation During Energy Restriction in Female Judo Athletes. June 2010. Journal of exercise science and fitness (JESF) 8(1):50-53

    [9] Oanton et al. Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (hmb) during resistance training. Nutrition. 2000 Sep;16(9):734-9.

    [10] Tischler et al. Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? J Biol Chem. 1982 Feb 25;257(4):1613-21.

    [11] Zanchi et al. Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies. Nutr Metab (Lond). 2008 Jul 17;5:20. doi: 10.1186/1743-7075-5-20.

    [12] Smith et al. Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss. Cancer Res. 2005 Jan 1;65(1):277-83.

    [13] Hoffman et al. Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training. Journal of Strength and Conditioning Research. 2004 Nov;18(4):747-52.

    [14] Nissen et al. Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol (1985). 1996 Nov;81(5):2095-104.

    [15] Kornasio et al. Beta-hydroxy-beta-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways. Biochim Biophys Acta. 2009 May;1793(5):755-63. doi: 10.1016/j.bbamcr.2008.12.017.

    [16] Thomson et al. Effects of nine weeks of beta-hydroxy-beta- methylbutyrate supplementation on strength and body composition in resistance trained men. J Strength Cond Res. 2009 May;23(3):827-35. doi: 10.1519/JSC.0b013e3181a00d4.

    [17] FAO/WHO/UNU (2007). "PROTEIN AND AMINO ACID REQUIREMENTS IN HUMAN NUTRITION". WHO Press., page 150 {http://apps.who.int/iris/bitstream/10665/43411/1/WHO_TRS_935_eng.pdf}

    [18] Slater et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. Int J Sport Nutr Exerc Metab. 2001 Sep;11(3):384-96.

    [19] O'Connor and Crowe. Effects of six weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on strength, power, and anthropometry of highly trained athletes. J Strength Cond Res. 2007 May;21(2):419-23.

    FAQs

    What are the Minimum daily intakes recommended by the WHO for Leucine?

    The WHO recommendation is 39 mg per KG of body weight for adult humans [17].

    Can HMB be used by athletes?

    At the present time the NCAA and the WADA have no issues with the use of HMB all natural treatment supplements. In 2006, it was estimated that around 1.9% of all collegiate athletes took HMB supplementation.

    Is HMB known to interact with hormones?

    Research involving young volleyball players has failed to identify any correlations with HMB consumption and the levels of Testosterone, Cortisol, or Growth Hormone [18].

    Is HMB known to interact with other nutrients?

    Research suggests that the combination of creatine and HMB may be additive with regards to supporting lean mass in healthy untrained individuals [19].

    Quick Questions

    HMB vs Creatine

    Creatine is thought to be more effective at supporting healthy levels of lean mass than HMB. However, the combination of the two seems to be additive in non-trained people.

    Is HMB supplementation thought to be safe?

    All of the research that has been performed points to standard doses of HMB being well tolerated in healthy individuals.

    How much HMB to take daily?

    People typically tend to take a dose of 3 mg per day. Many people working on gaining muscle calculate the amount to use on the basis of 38 mg per KG. Since there is no actual RDA you need to make the final decision yourself.

    Can I take HMB -

    with alcohol?

    It is not usually recommended to consume alcohol when following a stacking program.

    with food?

    Should be fine with small meals.

    with creatine?

    Yes this would be a commonly used stack.

    with testosterone?  

    HMB does not seem to have any influence on testosterone levels.

    For Crossfit?

    Many people into Crossfit take HMB

    For runners and cyclists? Yes, many people into running or belonging to a cycling group use HMB as a dietary supplement for its most positive benefits.

    Does it affect glucose levels in the blood and in urine?

    There is one report that it may support less sugar levels but much more significant research is required before any conclusive findings can be claimed.

    Does it affect cholesterol?

    The links between HMB, cholesterol, and cardiovascular health are quite ambiguous with different results reported by different research groups. It is often the case that any effects reported were similar to occurring when using a placebo.

    What about stacking HMB with BCAA, is it better?

    Many hardgainers choose to stack high calorie weight gainers, with HMB and a multivitamin. The full name for BCAAs is branched chain amino acids and they include leucine, valine, and isoleucine. They are often taken as an energy source in people serious about their training. HMB is of course a metabolite of leucine, and is thought to be especially beneficial to beginners wishing to support healthy muscle growth processes.

    Do I take HMB with or without food?

    Large amounts of glucose are thought to reduce the peak plasma concentration of HMB. Therefore many body builders and weight lifters tend to take it on an empty stomach or alongside a small meal.

    How many herb capsules are in a box and what dosage they do contain?

    There are 90 capsules (Vegicaps) per container. Each contains 1000 mg of HMB in the form of calcium B-Hydroxyl B-Methylbutyrate Monohydrate.

    Do people take HMB to relieve aching muscles?

    Yes many people take HMB to support muscle recovery.

    Where to buy HMB?

    Our HMB is available for sale right here and on our Amazon store.

    Can I take supplements to treat pain following working out?

    No these supplements are not designed to directly treat the pain caused by the build up of lactose acid.

    Does it have an affect upon bioenergetics?

    Supplementing HMB in rat adults (320 Milli- grams / kilogram) supported levels of ATP in white and red skeletal muscle.

    Are VitaMonk Products suitable for vegetarians?

    Yes our gluten free tablets and powders do not contain animal products.

    Your prices are very affordable.

    Yes they are, and not only that but we also offer free shipping on all orders over $35 if you buy online.


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