Magnesium L-Threonate

  • Magnesium L-Threonate is an all-natural ingredient that promotes activity and plasticity of neural synapses in the brain. It’s the ultimate supplement to supercharge your brain’s performance (and sleep better).

    Taking this regularly supports:

    • enhanced memory
    • improved quality of sleep
    • healthy nervous system functionality
     

      Supports Healthy Cognition, Learning, and Memory

      If you want to perform at your peak at your work or studies, Magnesium L-Threonate might help. When you take this supplement, it may support you to:

      • Promote activity in your brain’s hippocampus
      • Decrease your “brain fog” (and getting a memory boost
      • Enhance your brain cognition and problem solving
       

      Scientific studies suggest that Magnesium L-Threonate does indeed improve memory, problem solving and enhances cognition in healthy individuals.  Many healthy users report a decrease in brain fog from taking it regularly within a short time.

       

      Improve The Quality Of Your Sleep 

      Not only can you be more alert during the day, you can also sleep better (and get more rest) at night.

      Magnesium L-Threonate can help you:

      • Improve your sleep quality
      • Get more rest
      • Have more energy throughout the day

      Magnesium supplements are widely used as a sleep aid. They can induce deep sleep by working as natural relaxer to help calm your brain at bedtime. Giving you restful sleep and more energy - throughout the day.

       

      Encourage Healthy Nervous System Functionality

      Your body already uses magnesium in nerve communication and muscle response. Magnesium supplementation can support your central nervous system's overall function exhibiting benefits like:

      • Boosting your energy levels
      • Support central nervous system functionality

      Our Magnesium L-Threonate works exactly the same as the more expensive brands. With us, you’ll just get a better price.

       

      Natural, Safe, and Effective

      Vitamonk's products are manufactured in the USA and formulated by licensed doctors, while following strict GMP compliance standards. 

      We go to great lengths to make sure our supplements are 100% safe. When you use our supplements, you KNOW that you’ll only get the highest quality , all-natural ingredients (with no harmful fillers). They’re backed by science, and proven to get you results!

       

      We Guarantee Results Or Your Money Back

      We are so confident that you'll love our product, that it comes with a 100% money back guarantee.

      If for ANY reason your days aren't filled with more clarity or your sleep hasn't improved after taking this supplement, just let us know.  

      You’ll get 100% of your money back! (No questions asked.) 

      *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

    • Directions & Recommended Use:

      As a dietary supplement, take 3 capsules daily or as directed by your health care practitioner.

      Warning:

      Keep out of reach of children.  Do not use if pregnant, nursing, or under the age of 18.  Consult with a heath care professional if you have or suspect a medical condition, or before beginning any new dietary supplement.  If you experience any adverse reactions please discontinue use and contact your heath care professional.

       



      An Overview of Magnesium L-Threonate

      • Supports short- and long-term memory
      • May Improve Learning
      • Supports response to anxiety
      • Supports synaptic action

      Magnesium L-threonate (MgT) is a highly absorbable form of magnesium able to cross the blood-brain barrier and to easily force its way through cell membranes.

      Unlike most dietary magnesium supplements, magnesium L-threonate is not generally used to overcome magnesium deficiencies but is used to support cognitive function. If you are only looking to address general magnesium deficiency you may wish to take magnesium citrate (typically at a dose of 200 to 400 mg).

      Chelations with the vitamin C metabolite L-threonate (threonic acid) are known to enhance mineral bioavailability. In this case, it allows magnesium to be better delivered to the parts of the body, such as the brain, where it is required. It has been reported that the bioavailability of magnesium taken in the form of magnesium L-threonate is enhanced when dissolved in milk [1]. The bioavailability in the brain is also much greater than seen with most other forms of magnesium tablets e.g. magnesium glycinate and magnesium oxalate [2].

      Memory and Cognition

      With regards to the brain, learning and memory are fundamental functions that can be affected by both environment and diet. When taken orally, magnesium L-threonate has been shown to support memory (long and short term), enhance learning abilities, and improve working memory in rats [1].

      In older rats there was also a positive effect on the maintenance of task completion ability. The same scientific research work also reported that a higher density of synaptophysin- (synaptic vesicle protein p38) and/or synaptobrevin-positive puncta occurred in certain subregions of the hippocampus strongly correlated with improved memory functions. The group also suggested that synaptic plasticity was enhanced in rats. Therefore using magnesium L-threonate to help promote levels of magnesium in the brain is likely to support synaptic facilitation, potentiation, memory, and learning in healthy individuals.

      Further research has suggested that elevation of magnesium levels in the brain can help to support a healthy response to anxiety and other mental mechanisms [3]. Elevated magnesium is thought to enhance plasticity in the hippocampus and the prefrontal cortex. The researchers demonstrated that increased magnesium levels resulted in an increase of signaling involving NMDA receptors and increased presynaptic puncta density in the prefrontal cortex in relation to fear memory in rats, these phenomena did not occur in the basolateral amygdala, suggesting that brain magnesium may act in a regional specific manner in the memory formation processes [3].

      What is the Role of Magnesium in the Body

      Magnesium (Mg2+) is an abundant mineral that is found in many foods. Despite this its intake levels in the general US population is lower than the RDA provided by the Food and Nutrition Board [4]. Some of the foods that are naturally rich in magnesium include almonds, cashews, edamame beans, salmon, soymilk, broccoli, peas, and spinach.

      Severe deficiency is rare and tends to occur in people with diseases, especially those related to the kidney (which plays a major role in magnesium homeostasis, with around 120 mg of Mg being excreted by urine per day).

      An adult body typically contains around 25 grams of magnesium. The majority of which is stored in cells and in the bones (50 to 60%), where it has a major role in bone structure and remodeling. It is also needed for RNA and DNA synthesis, energy production, glycolysis, oxidative phosphorylation, and for use by the glutathione antioxidant. The levels of magnesium in blood serum are kept under strict control, and typically range from 0.75 and 0.95 mmol)/L [5].

      Magnesium has been reported to support cardiovascular health [6], help support healthy blood sugar levels (most likely through its role in glucose metabolism)[7], to influence osteoblast and osteoclast activity and concentrations of vitamin D during bone formation and removal [8], it is also associated with neurotransmitter release [9], so healthy levels of the mineral may help support a healthy response to headaches.

      Understanding the Research into the Role of Magnesium L-Threonate as a Brain Booster

      Research into the use of magnesium as a ‘brain booster’ in humans is currently being performed by Magceutics with the aim of better delivering and increasing levels of magnesium ions in the brain. Some of the research aspects of the Magtein supplement investigated included responses to anxiety and sleep quality.

      Dr. Guosong Liu, a neuroscientist from Tsinghua University in Beijing, is leading this research. His team previously demonstrated the role of the NMDA receptor 2B (NR2B) in increasing memory in the brain of mice through the strengthening of synaptic connections [10]. The group later went on to demonstrate the role of magnesium in supporting synaptic changes [11] and in promoting healthy memory [1].

      Sleep quality has also been suggested to be enhanced in humans, in older people [12].

      Further research at the Max Planck Institute of Psychiatry in Germany by Harald Murck strongly supports that intravenous magnesium may support cognitive function during sleep [13]. As Magnesium L-threonate is able to deliver magnesium across the blood-brain barrier to areas where it is required by the brain it may support cognition in healthy individuals.

      Further Reading

      • Reddit: Can this nootropic be used as a sleep aid? {https://www.reddit.com/r/Nootropics/comments/2r8cnh/magnesium_lthreonate/}
      • Quora:  How helpful is Magnesium l threonate with memory? {https://www.quora.com/unanswered/How-helful-is-Magnesium-l-threonate-with-memory-treatment-resistant-depression-OCD-PTSD-chronic-pain-balancing-the-glutamate-system}
      • National Institutes of Health: Magnesium Fact sheet for Health professionals {https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/}
      • WebMD: Are you getting enough magnesium in your diet?  {http://www.webmd.com/diet/supplement-guide-magnesium#1}
      • Drugs.com: Magnesium Uses, Dosage & Side Effects {https://www.drugs.com/magnesium.html}
      • Nature: Testing magnesium's brain-boosting effects
      • {http://www.nature.com/news/testing-magnesium-s-brain-boosting-effects-1.11665}

      Citations, Reviews, and References

      [1] Slutsky et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77. doi: 10.1016/j.neuron.2009.12.026.

      [2] Bush. Kalzium ist nicht alles. Neuron. 2010 Jan 28;65(2):143-4. doi: 10.1016/j.neuron.2010.01.015.

      [3] Abumaria et al. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci. 2011 Oct 19;31(42):14871-81. doi: 10.1523/JNEUROSCI.3782-11.2011.

      [4] Moshfegh et al. What We Eat in America, NHANES 2005-2006: Usual Nutrient Intakes from Food and Water Compared to 1997 Dietary Reference Intakes for Vitamin D, Calcium, Phosphorus, and Magnesiumexternal link disclaimer. U.S. Department of Agriculture, Agricultural Research Service

      [5] Elin. Assessment of magnesium status for diagnosis and therapy. Magnes Research. 2010 Dec;23(4):S194-8. doi: 10.1684/mrh.2010.0213.

      [6] Del Gobbo. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr. 2013 Jul;98(1):160-73. doi: 10.3945/ajcn.112.053132

      [7] Rodríguez-Morán et al. The role of magnesium in type 2 diabetes: a brief based-clinical review. Magnes Res. 2011 Dec;24(4):156-62. doi: 10.1684/mrh.2011.0299.

      [8] Rude et al. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr. 2009 Apr;28(2):131-41.

      [9] Sun-Edelstein and Mauskop. Role of magnesium in the pathogenesis and treatment of migraine. Expert Rev Neurother. 2009 Mar;9(3):369-79. doi: 10.1586/14737175.9.3.369.

      [10] Tang et al. Genetic enhancement of learning and memory in mice. Nature. 1999 Sep 2;401(6748):63-9.

      [11] Slutsky et al. Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity.Neuron. 2004 Dec 2;44(5):835-49.

      [12] Held et al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Send to Pharmacopsychiatry. 2002 Jul;35(4):135-43.

      [13] Murck and Steiger. Mg2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men -- possible therapeutic implications. Psychopharmacology (Berl). 1998 Jun;137(3):247-52.

      [14] Spencer et al. Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. Journal of the American College of Nutrition. 1994 Oct;13(5):479-84.

      FAQs

      What is the recommended dietary allowance for magnesium?

      For Adult males 19 to 30 it is 400 mg, for men above 30 it is 420 mg. For women 19 to 30: 310 mg; 31+ 320 mg (Pregnant, aging, and lactating women are recommended to take a slightly higher amount: see the NIH site for further details.

      Which foods are rated high in magnesium?

      If you want to increase the amount of foods rich in magnesium in your diet you should include plenty of green leafy vegetables, nuts, cereals, bread, yoghurt, and potatoes. A single serving of Almonds or spinach is enough to provide 20% of the daily value as recommended by the FDA.

      Unfortunately, most people don’t eat well and so it is no surprise that many do not gain enough minerals and vitamins through their diet in the long term despite making short term efforts, so it may be best for them to take all natural supplements to make up for these shortfalls.

      It should also be noted that the L-threonate form of magnesium supplementation is much more bioavailable and is able to cross the blood brain barrier and hence better support cognition than the more standard forms of supplements such as milk of magnesia (Magneisum Hydroxide (MgOH2), Diglycinate, and Orotate (Orotic acid).

      Are there any risks associated with taking magnesium supplements?

      There are a few reported side effects such as cramps, nausea, stool softening, and diarrhea.

      Do other mineral supplements interfere with magnesium uptake?

      Yes, very high amounts of zinc can affect its absorption and balance [14].

      Can magnesium interact with medications?

      Yes, if you are taken any form of medication treatment you should consult with your doctor or medical practitioner before taking any supplements. Just some of the things that Mg is known to interact with include bisphosphonates, antibiotics, diuretics, and proton pump inhibitors.

      Why is there so little research into the use of Magnesium L-Threonate?

      One of the major problems in the research of the use of common vitamins and minerals thought to support cognition is that they are readily available and relatively cheap to buy, hence there is a lack of research funding and investigation from the big life science pharmaceutical companies.

      Quick Questions

      What is magnesium l-threonate used for? It is used as a natural dietary supplement to deliver magnesium to the body effectively.

      What does it do?

      The l-threonate helps to deliver magnesium across the blood brain barrier.

      How much magnesium l-threonate should I take?

      The serving size is three capsules.

      What is the role of synapses in the brain?

      A synapse is a structure that allows nerve cells (neurons) to pass electrochemical signals to each other.

      Where can I buy it?

      We sell our affordable all natural pills right here online. They are also available from us on Amazon.

      Can I use magnesium l-threonate for sleep?

      Some of the research performed on animals (rats) was related to sleeping.

      Magnesium l threonate

      • vs magnesium malate
      • vs magnesium orotate
      • vs magnesium sulfate
      • vs magnesium oxide
      • in comparison with magnesium glycinate
      • compare with citrate

      (Both magnesium l threonate and magnesium gluconate are thought to have better absorption than the above forms.)

      Are VitaMonk tablets and powder gluten free?

      Yes, and our Vegeicaps capsules are also suitable for vegetarians.

      Where is this VitaMonk product manufactured?

      All of our high quality VitaMonk products are proudly made in the USA. We welcome any feedback that you may have for any of our brands.

      Do you offer free shipping if I buy online?

      Yes, add to the cart and you’ll see that we offer free delivery for purchase orders with a price of $35 and over.


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