DIM
diindolylmethane (DIM)
NutraDIM™ DIM (Diindolylmethane)
NutraDIM™ DIM (Diindolylmethane)
VitaMonk DIM Supplement
DIM
diindolylmethane (DIM)
NutraDIM™ DIM (Diindolylmethane)
NutraDIM™ DIM (Diindolylmethane)
VitaMonk DIM Supplement

NutraDIM™ DIM (Diindolylmethane)

$19.99

NutraDIM™ is a high quality DIM (or diindolylmethane) supplement. DIM is a natural component of I3C (indole-3-carbinol), found in healthy vegetables like broccoli, kale and cauliflower. These delicious vegetables are widely regarded as superfoods for this very reason.

Scientifically shown to have powerful effects on estrogen metabolism, this supplement can support: 

  • A healthy and balanced estrogen level (in both men and women)
  • Menopause and estrogen dominance (in women)
  • Estrogen blocking for bodybuilders (in men) - increasing the ratio of testosterone to estrogen
  • Enhanced energy and libido
  • Weight loss, strong heads of hair and clear skin (clearing noncystic hormonal acne)
  • Overall healthy estrogen metabolism 

If you’re trying to minimize the estrogen flowing through your body, (and reap the countless health benefits) - DIM should be a key part of your daily supplement regimen.

Promotes Healthy Estrogen Metabolism & Normal Hormone Levels

With its potent effects on your estrogen metabolism, DIM is a powerful way to balance the hormone estrogen in your body (by preventing either drastic increases or decreases).

DIM is a natural substance generated when the body breaks down I3C, commonly found in healthy vegetables like broccoli and kale.

It can inhibit an enzyme converting testosterone to estrogen, and it can even convert more potent forms of estrogen into LESS potent forms. In very large doses, it can work the other way around, and increase estrogen synthesis.

This means that you can use DIM to balance the estrogen in your body to the healthy level you want. 

Use NutraDIM™ to maintain balanced estrogen levels in your body, and healthy estrogen metabolism.

NutraDIM™ DIM (Diindolylmethane)

Get Support During And Menopause

DIM is a key supplement in helping women maintain balanced estrogen levels. 

It promotes healthy estrogen levels, commonly used to support: 

  • Healthy menopause
  • Get and maintain strong hair and clear skin
  • Enhanced weight loss, energy and libido
  • Management of noncystic hormonal acne

DIM can serve as such an effective estrogen blocker that it’s also commonly used by MEN - quickly becoming one of the most popular bodybuilding supplements on the market by helping to optimize the testosterone-to-estrogen ratio.

NutraDIM™ DIM (Diindolylmethane)

Safe, and Effective

VitaMonk's products are formulated by licensed doctors and manufactured in state-of-the-art facilities following strict GMP compliance standards.

We go to great lengths to make sure our supplements meet the highest safety standards. When you use our supplements, you KNOW that you’ll only get the highest quality ingredients that have the most scientific backing to help you get results.

NutraDIM™ DIM (Diindolylmethane)
Get NutraDIM™ DIM (Diindolylmethane)

We are so confident that you'll love this product that it comes with a 100% money back guarantee. If for any reason you’re not completely satisfied with this supplement after using it, just let us know.

A Look at Diindolylmethane – DIM, with Black Pepper Extract

  • Supports balance of the sex hormones estrogen and testosterone
  • Likely to enhance libido
  • May help to support a healthier weight
  • Supports healthy menopause in women
  • May support efficient blocking of estrogen in men looking to build muscle mass

The body produces Diindolylmethane (DIM) during the digestive breakdown of the phytochemical indole-3-carbinol (I3C). Thus I3C acts a precursor of 3,3′-Diindolylmethane.

This glucosinolate phytochemical is naturally found in members of the Brassica plant family, such as broccoli, cabbage, cauliflower, and Kale. One of the main reasons why these green cruciferous vegetables are considered to be a healthy food is because of their natural high content of I3C / DIM [1]. 

Due to its potential role in the support of healthy cell growth a lot of current research focuses on the role that DIM plays as a histone deacetylase inhibitor. DIM is also strongly associated with supporting the control of estrogen at healthy levels, and may be involved in the support of genetic repair mechanisms.

As a source of piperine, black pepper is able to play a role in the inhibition of detoxifying enzymes involved in glucuronidation in the liver. It may help to support the uptake of molecules in the body, and so help to maintain the bioavailability of supplements and drugs [2]. Other active components of black pepper spice extract include guineensine, pellitorine, piperonal, pipnoohine, and trichostachine [3].

Sex Hormone Homeostasis

DIM is thought to play a role in balancing the homeostasis of the sex hormones estrogen and testosterone. As estrogen is broken down in the body it is converted into metabolites. Depending on their type these may be either beneficial or harmful for human health. DIM may help to support the levels of healthy 2-hydroxyestrone, and to lower the levels of unhealthier estrogenic metabolites. DIM is also thought to play a role in preventing any major deviations from the norm, and thus prevent spiking of hormone levels.

DIM is able to activate estrogen receptor ERα and ERβ subsets [4]. The mechanisms mediated by these receptors are thought to occur indirectly.

The activation of ERα is thought to act in both a cell dependent and dosage dependent manner. DIM has been demonstrated to have an effect on cell proliferation through stimulating cell growth via the estrogen receptor α signaling pathway at low dosage levels [5]. This growth acts independently of 17β-estradiol and also involves the protein kinase A signaling pathway.

DIM is able to stimulate the binding of regulatory elements by ERβ and to activate ER target genes through the recruitment of a steroid receptor coactivator [4]. 

DIM is thought to have a role in the modification of estrogen steroids via the 2-hydroxylation process. This role is thought to be secondary to its role in inducing AhR responsive genes [6]. The 2-hydroxylation process involves alteration of the 2-hydroxyestrone to 16α-hydroxyestrone ratios [7], and hence may lead to a lowering of the overall estrogenic profile. This has an overall effect of changing estrogen into a less potent form, and thus lowering the biological impact of the hormone in the body.

When taken orally DIM may help to support healthier levels of urinary 2-hydroxyestrone concentrations in women [8]. 2-hydroxyestrone has been speculated to be a beneficial estrogen with regards to women’s health [8]. 

DIM may inhibit the activation of the adrenal enzyme aromatase. This enzyme is involved in testosterone to estrogen conversion [9]. It has been demonstrated to affect the levels of dihydrotestosterone (DHT) in the prostate independently of the androgen receptor. This inhibition of conversion of testosterone into estrogen may affect the ratios of these two sex hormones and thus may prove of interest to people in the bodybuilding community. 

Weight Control 

In obese mice undergoing a high fat diet, the injection of 5 mg per KG of I3C (the precursor of DIM) was observed to affect numerous factors associated with obesity. I3C treatment supported healthy glucose tolerance, and healthier insulin and leptin concentrations in the mice. Overall, there was a decrease in body weight and in the accumulation of fat in the indole-3-carbinol treated mice group [10].

    Citations, Abstract, Review, and References 

    [1] Minch and Bland. A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals. Nutr Rev. 2007 Jun;65(6 Pt 1):259-67.

    [2] Han. The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opinion on Drug Metabolism Toxicology. 2011 Jun;7(6):721-9. doi: 10.1517/17425255.2011.570332.

    [3] Rao et al. Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. Nat Prod Res. 2011 Aug;25(13):1288-94. doi: 10.1080/14786419.2010.535158. 

    [4] Vivar et al. Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane. Endocrinology. 2010. 151 (4): 1662-1667. DOI: 10.1210/en.2009-1028. 

    [5] Auborn et al. Indole-3-carbinol is a negative regulator of estrogen. J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S.

    [6] Jellinck et al. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol. 1993 Mar 9;45(5):1129-36. nutr

    [7] Chen et al. Within-person variability of the ratios of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone in Caucasian women. Steroids. 1999 Dec;64(12):856-9. 

    [8] Bradlow et al. 2-hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65. 

    [9] Biegon. In vivo visualization of aromatase in animals and humans. Front Neuroendocrinol. 2016 Jan;40:42-51. doi: 10.1016/j.yfrne.2015.10.001. 

    [10] Chang et al. Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice. Nutrition. 2011 Apr;27(4):463-70. doi: 10.1016/j.nut.2010.09.006.

    Further Reading 

    • WebMD: {1} Vitamins & Supplements: User Reviews & Ratings {http://www.webmd.com/vitamins-supplements/ingredientreview-1049-DIINDOLYLMETHANE.aspx?drugid=1049&drugname=DIINDOLYLMETHANE&pageIndex=1&sortby=3&conditionFilter=-500 } 
    • {2} An helpful explanation of Telomeres, Gene Expression activity and interactions, & Toxicology and Apoptosis, {http://forums.webmd.com/3/heart-health-fuhrman-ornish/forum/246/2}
    • Drugs.com: Broccoli (Brassica oleracea L. var. botrytis L) glucosinolates: the isothiocyanates sulforaphane, I3C, and 3,3-DIM.
    • Reddit:
      • {1} The Power of DHT: steroids {https://www.reddit.com/r/steroids/comments/2r9xms/the_power_of_dht/}
      • {2} Have any of you taken DIM? {https://www.reddit.com/r/acne/comments/46x97m/have_any_of_you_taken_dim_also_known_as/}
    • Quora: Are there any effective testosterone boosters? {https://www.quora.com/Are-there-any-effective-testosterone-boosters} 

    What foods are high in DIM?

    If you want to include DIM naturally in your diet then you may wish to eat more of the following Indole-3-Carbinol rich cruciferous vegetables: Bok Choy; Broccoli; Brussels sprouts; Cabbage (Red, Savoy) Cauliflower; Collard greens, Horseradish, Kale; Kohlrabi; Mustard; Rutabaga, Turnip, and watercress. The vegetables with the highest natural IC3 content are cress (392 mg / 100 g), greens (282 mg/100 gram), and turnips (92 milligrams per hundred grams). You will need to eat a lot of raw vegetables everyday to get the same amount of DIM that is contained in our NutraDIMTM product.

    Does cooking affect glucosinolates levels?

    Yes, most people eat cooked vegetables. Heating has a negative effect on the oral bioavailability of glucosinolates such as IC3. This is largely because the enzyme Myrosinase (which is involved in glucobrassicin metabolism) is destroyed / deactivated with the increase in high temperatures and so cannot convert DIM at maximal rates. If you plan to get DIM from you diet it is best to eat your vegetables like I do, I eat my vegetables raw. 

    Do people stack DIM with other compounds?

    People interested in increasing their athletic performance may often take DIM alongside testosterone boosters.

    What is diindolylmethane good for?

    It helps to balance the peaks and troughs of estrogen, and supports the levels of the healthier estrogen metabolites. 

    Where does diindolylmethane come from?

    Indole-3-carbinol is found naturally in cruciferous vegetables, this compound is converted into DIM during the digestion process. Some Brassica are also a direct source of the compound. 

    What does the abbreviation DIM stand for?

    The full IUPAC name is 3,3′-methanediylbis(1H-indole), it is also often referred to as 3-(1H-Indol-3-ylmethyl)-1H-indole. 

    Why do people use diindolylmethane / Why take DIM?

    To support estrogen metabolism and to help balance steroidal hormone homeostasis.

    What is diindolylmethane good for?

    It helps to support estrogen homeostasis.

    How does diindolylmethane work?

    The breakdown of estrogen in the body results in both good and bad metabolites. DIM benefits include that it helps to support the levels of beneficial low estrogenic metabolites. 

    How does exercise affect estrogen?

    Exercise typically results in greater levels of beneficial low estrogenic metabolites such as 2-hydroxy estrogens and 2-methoxy estrogens, while lowering the levels of highly estrogenic metabolites that may damage the body such as the 16-hydroxy estrogens [7]. 

    How much diindolylmethane to take?

    There is no RDA or minimum daily recommendation (MDR) for DIM. VitaMonk capsules contain 200 mg DIM per serving. They also contain 3 mg of black pepper extract.

    Are they suitable for vegetarians?

    Yes, in addition to the active compounds mentioned above the only other ingredients a NutraDIM capsule contains are magnesium stearate, tapioca, white rice flour, and vegetable Cellulose. We even name our vegetarian friendly gluten free capsules Vegicaps.

    Is DIM Safe?

    Although it is largely considered to be safe, taking excessive dosages may result in side effects such as headaches and gastrointestinal issues. As with all drugs and supplements it is always wise to take advice from your general practitioner / doctor before starting any supplement taking regime. 

    What about free shipping if I buy them online?

    There is no shipping charge on all VitaMonk products orders of $35 and over.

    Where can I buy high quality DIM?

    We sell it online here, and you can also find it for sale on our Amazon store.