Policosanol 20mg

  • Having a strong, healthy heart is essential to living a long, healthy and enjoyable life

    Policosanol is a natural mixture of extracts that may promote the health of your heart and blood vessels.

    Regular use of this supplement may support:

    • Healthy cholesterol levels
    • Healthy cardiovascular function
    • Improved blood circulation
    • Healthy cardiovascular lipid levels
     

    These therapeutic effects make this supplement a perfect complement to a healthy diet and daily exercise for support of your cardiovascular system!

     

    Manage Healthy Cholesterol Levels Naturally

    Policosanol has been shown to support healthy levels of cholesterol, triglycerides and lipids in the blood (when already in a normal range).

    Over 80 scientific studies have been published on policosanol derived from sugar cane, documenting its’ positive effects.

    These studies show that this substance can support management of LDL (bad cholesterol) levels, while promoting HDL (good cholesterol) levels.

     

    Supports Healthy Cardiovascular Function

    Policosanol may also support healthy blood circulation, and promoted levels of healthy cardiovascular lipids.

    As a potent antioxidant, it also supports inhibition of platelet aggregation - helping healthy individuals with cramping muscles caused by poor circulation.  

    By supporting blood thinning and healthy lipid levels, it may also support healthy circulation and blood flow.

     

    Natural, Safe, and Effective

    VitaMonk's products are formulated by licensed doctors and manufactured in state-of-the-art facilities following strict GMP compliance standards.

    We go to great lengths to make sure our supplements meet the highest safety standards. When you use our supplements, you KNOW that you’ll only get the highest quality ingredients that have the most scientific backing to help you get results.

     

    We Guarantee Results Or Your Money Back

    We are so confident that you'll love our product, that it comes with a 100% money back guarantee.

    Try it now with NO RISK. If for ANY reason you’re not completely satisfied with this supplement after using it, just let us know.  

    You’ll get 100% of your money back! (No questions asked.) 

    *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

  • Directions & Recommended Use:

    As a dietary supplement, take one capsule daily or as directed by your health care practitioner.

    Warning:

    Keep out of reach of children. Do not use if pregnant, nursing, or under the age of 18. Consult with a heath care professional if you have or suspect a medical condition, or before beginning any new dietary supplement. If you experience any adverse reactions please discontinue use and contact your heath care professional.



Policosanol Overview

Policosanol is a natural mixture of higher aliphatic primary alcohols shown to be effective at supporting healthy levels of cholesterol.

It may also have possible health benefits for cognition, cardiovascular diseases, preservation of bone mass, and in supporting acetylcholine release at neuromuscular junctions.

Policosanol is the name for a group of natural phytochemicals primarily derived from waxes of the sugar cane plant (Saccharum officinalis). It is also found in many other plant species such as Rice, Wheat, and Perilla. In addition to plants, Policosanols are also present in Beeswax.

The main constituent of Policosanol in Cuban sugar cane waxes is octacosanol (octacosyl alcohol; 63% of the total primary aliphatic alcohols). Other major components include triacontanol (13%) and hexacosanol (6%). Numerous Cuban research papers, have suggested that Policosanol is effective at supporting healthy levels of low-density-lipoprotein (LDL) cholesterol and total cholesterols in a similar manner as statins, such as simvastatin or pravastatin[1, 2, 3].

What are Lipoproteins? Understanding Good and Bad Cholesterol

The main purpose of lipoproteins is to transport fat molecules in watery environments, such as the blood and extracellular fluids.

They typically consist a single phospholipid layer with an outer shell of cholesterol. There are five main classifications of lipoproteins: Chylomicrons; VLDL; IDL; LDL-cholesterol; and HDL.

The size of lipoproteins increases, and their density decreases, when the ratio of fat to protein increases.

Perhaps the two most known classes of lipoprotein are HDL (30% cholesterol) and LDL (50% cholesterol).

Bad Cholesterol: LDL is often referred to as ‘bad cholesterol’. Their levels correlate with hardening and narrowing of the arteries.  A typical LDL carries three to six thousands molecules of fat.

Good Cholesterol: HDL is often referred to as ‘good cholesterol’. Their levels correlate with supporting correct artery function. They are involved in removing fats from cells and tissues and in delivering them to the liver.

Policosanol Biological Processes

The actual mechanisms of how Policosanol works have not been fully elucidated. It is thought they mainly act by inhibiting hepatic cholesterol synthesis before formation of mevalonate occurs. The mevalonate pathway (isoprenoid pathway) is involved in the synthesis of cholesterol, and of non-steroid isoprenoids such as heme-A and ubiquinone. It therefore plays important roles in cell growth and differentiation.

Policosanol Supports Cholesterol in Healthy Individuals

It has been reported that Policosanal can increase the activation of the kinase AMPK in the liver by over 2-fold in rats[4]. This kinase is involved in cellular energy homeostasis. Inhibition of AMPK has been shown to reduce cholesterol synthesis . It is thought that the reduction in cholesterol synthesis is an indirect result of inhibition of HMG-CoA.

Much research points to Policosanol supplementation supporting more correct levels of bad LDL cholesterol and good HDL cholesterols; thus maintaining a more balanced level of overall cholesterol.

Much of the research into Policosanol has been performed on people with high levels of cholesterol in their blood (high blood lipids) due to poor lifestyle and dietary habits.

The research demonstrated strong support for recovering a more healthy range in their levels of cholesterol [2,5,6,7]

Policosanol has also been linked to LDL oxidation and in cardiovascular support. The evidence for these findings is quite weak, and may actually have come about as a result of the dietary controls used in the research work.

Policosanol and Bone Strength

Supplementation with Policosanol has been demonstrated to preserve bone mass in menopausal rats[8]. It is thought that this comes about through an indirect inhibition of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A).

This results in a lower level of the cholesterol precursor mevalonate; which plays a role in osteoclast production. An osteoclast is a specialized bone cell that is involved in breaking down bone tissue in the bone remodelling cycle.

Dosage

The majority of research studies into the effectiveness of the Policosanol has been performed at dosages of 10 to 20 mg per day.

At this level, research suggests that total cholesterol, LDL cholesterol, and good cholesterol (high-density lipoprotein cholesterol (HDL)) were supported to a more healthy levels.

Increasing Policosanol Dosage: 40 mg vs 20 mg

For people looking to control excess levels of cholesterol in the bloodstream the effective dose suggested to support healthier levels of cholesterol ranges from 5 mg to 20 mg.

A study by Castano and colleagues [3] revealed that increasing the dosage to 40 mg per day did not offer any major additional cholesterol support than a 20 mg dose.

In a six month human trial conducted of people with high cholesterol levels (hypercholesterolemia), they reported that 20 mg of Policosanol supported a more healthy level of LDL cholesterol, of total cholesterol, and on the ratio of LDL::HDL. This ratio decrease was largely a result of a  support of the HDL-cholesterol levels.

Overall, there was slightly greater support of triglycerides levels at a 40 mg daily dose in the medical trials in comparison with the 20 mg daily dose.

Although it appears that a larger dose has a slightly greater impact on supporting cholesterol levels, the authors reported that the effects were practically identical at both doses and that no unexpected adverse significant effects were observed at the two different dosages[3].

Possible Interactions

Aspirin: There is evidence that Aspirin works synergistically with fatty acids found in Policosanol. When given together to rats and rabbits there was a negative effect in that bleeding time increased, thus preventing the formation of platelets; however there was a reported 33% increase in survival rates in response to blood clotting stimuli.

Fish Oil: though there is not much evidence for synergy between fish oil and Policosanol both are reported as being beneficial for lipoprotein. Although Fish oil reduces the overall levels of triglycerides it may increase and restore levels of LDL cholesterol. The combination of fish oil and Policosanol further supported healthy levels of  LDL and triglycerides [10].

With regards to cognition, the combination of fish oil and Policosanol has been linked to minor increases in lifting mood and in reducing reaction times.

CoQ10: This coenzyme is found in the mitochondria where it is involved in energy production. It is often given as a supplement in people prescribed statins, as CoQ10 levels are reduced through inhibition of the enzyme HMG-CoA; which can result in tiredness.

As Policosanol may work in a similar manner to statin, it has been suggested that supplementation with coenzyme Q10 could be beneficial.

In rabbits, it has been reported that taking red yeast extract supplement alongside policosanols has additive effects regarding the support of healthy cholesterol levels.

It is arguable whether there is an addictive association between the use of the blood thinning drug Warfarin and Policosanol. As some nutraceuticals are known to interact adversely with Warfarin, it is recommended that you take a health professional’s advice before taking Warfarin with any kind of natural functional foods and supplements.

References Cited

[1] Francini-Pesenti et al. Effect of sugar cane policosanol on lipid profile in primary hypercholesterolemia. Phytother Res. 2008 Mar;22(3):318-22. doi: 10.1002/ptr.2315.

[2] Castaño et al. Effects of policosanol on older patients with hypertension and type II hypercholesterolaemia. Drugs R D. 2002;3(3):159-72.

[3] Castaño et al.  Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. Int J Clin Pharmacol Res. 2001;21(1):43-57.

[4] Cabrera et al. Study of the stability of tablets containing 10 mg of policosanol as active principle. Boll Chim Farm. 2002 May-Jun;141(3):223-9.

[5] Torres et al. Treatment of hypercholesterolemia in NIDDM with policosanol. Diabetes Care. 1995 Mar;18(3):393-7.

[6] Castaño et al. Effects of policosanol on postmenopausal women with type II hypercholesterolemia. Gynecol Endocrinol. 2000 Jun;14(3):187-95.

[7] Canetti et al. A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia. Int J Clin Pharmacol Res. 1995;15(4):159-65.

[8] Noa et al. Policosanol prevents bone loss in ovariectomized rats. Drugs Exp Clin Res. 2004;30(3):117-23.

[9] Molina et al. Synergistic effect of D-003 and aspirin on experimental thrombosis models. Prostaglandins Leukot Essent Fatty Acids. 2003 May;68(5):305-10.

[10] Castaño et al. Effects of addition of policosanol to omega-3 fatty acid therapy on the lipid profile of patients with type II hypercholesterolaemia. Drugs R D. 2005;6(4):207-19.

Further Citations from Pubmed 

  • Buhaescua and Izzedineb. Mevalonate pathway: A review of clinical and therapeutical implications. Clinical Biochemistry, Volume 40, Issues 9–10, June 2007, Pages 575–584. ndez
  • Elseweidy et al. Policosanol as a new inhibitor candidate for vascular calcification in diabetic hyperlipidemic rats. Exp Biol Med (Maywood). 2016 Nov;241(17):1943-1949.
  • Kabir and Kimura. Tissue distribution of (8-14C)-octacosanol in liver and muscle of rats after serial administration. Ann Nutr Metab. 1995;39(5):279-84.
  • Gouni-Berthold and Berthold. Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J. 2002 Feb;143(2):356-65.
  • Santini and Novellino. Nutraceuticals in hypercholesterolaemia: an overview. Br J Pharmacol. 2016 Sep 29. doi: 10.1111/bph.13636.
  • Solomenchuk et al. Efficiency of concomitant use of policosanol and rosuvastatin in patients with stable coronary artery disease and moderate hepatic dysfunction (abstract). Lik Sprava. 2015 Oct-Dec;(7-8):29-37.

Further Reading and Helpful Information

  • Drugs.com: [https://www.drugs.com/npp/policosanol.html]
  • Examine: [https://examine.com/supplements/Policosanol/]
  • Medscape: [http://www.medscape.com/viewarticle/456944]
  • Reddit: Fitness compare pages [https://www.reddit.com/r/Fitness/]
  • WebMD: Alternative Treatments for High Cholesterol [http://www.webmd.com/cholesterol-management/guide/high_cholesterol_alternative-therapies#1]; Cholesterol Management 101 [http://blogs.webmd.com/cholesterol-management/2010/02/herbal-medicines-cholesterol-part-1.html]
  • Wikipedia: Policosanol’s and metabolism [https://en.wikipedia.org/wiki/Policosanol]

FAQs

Does Policosanol affect blood sugar levels?

Although Policosanol is derived from sugar cane it is actually a group of eight long-chained alcohols and therefore not a sugar itself. Thus it is expected to have no direct impact on blood sugar / glucose levels.

Why does most of the research into Policosanol health benefits derive from Cuba?

Sugar cane is an important cash crop in Cuba, it is therefore a focus of much of the country’s agricultural and alternative medicine research programs.

Should I buy Sugar Cane Extract wax or Bees wax derived Policosanol?

All the in vitro and in vivo evidence for Policosanol supporting healthy levels of total cholesterol comes from sugar cane research. Recent research papers have not revealed any correlation between bees wax derived higher aliphatic primary alcohols and cholesterol levels.

Cardiovascular support: Is Policosanol good for a Healthy Heart?

Policosanol is linked with numerous associated cardiovascular benefits because of its effects on cholesterol. These include factors such as LDL oxidation; smooth muscle proliferation; and platelet aggregation.

What are some of the reasons people take Policosanol?

  • Supporting healthy levels of bad cholesterol
  • Supporting overall cholesterol
  • Improving blood circulation
  • Triglycerides
  • To improve heart health
  • Supporting correct blood lipid levels
  • Bone strength
  • Blood pressure
  • Brain reaction time

How long does it take to work?

Most of the research into this product showing positive impacts has been performed over six month periods.

What is it often taken with?

Policosanol all natural treatment is often taken alongside Aspirin, Fish oil, and/or CoQ10.

Are VitaMonk supplement capsules, tablets, and pills suitable for vegetarians and seniors?

Yes, our gluten free vegicaps are suitable and safe for vegetarians. In addition to 95% Policosanol, the other ingredients in the product are brown rice flour, Magnesium stearate, and Hypromellose.

Were the scientific trials performed randomized?

The trials  were controlled and made use of placebo methods over a number of weeks.

Where does policosanol come from/ what foods contain it?

Foods that Policosanol is found naturally in include Cuban sugar cane, Wheat germ, Peanuts, Perilla seeds, Rice (Oryza sativa), Switchgrass, Guduchi, Pomegranate seeds, and in oils such as Sesame, Soybean and Maize/Corn. So you may wish to include some of these in your diet. If taken on the side none of these are likely to have an influence on any excess KG.

Does taking supplements act as a natural remedy to relieve other conditions?

Policosanol is thought to provide natural support for healthy cholesterol levels, it should not be considered as some kind of cure all relief remedy.

How much should I take?

Most of the noted research work for men and for women that has been performed uses from 5 mg to 40 mg of policosanol.

Each VitaMonk tablet contains 20 mg of 95% Policosanol. Many people may wish to to cut up one tablet and take a lower dose twice daily.

How many tablets in a bottle? How many ml /dl in total?

Each bottle contains 100 capsules. Compare this with our rivals!

Where to buy Policosanol near me?

You can purchase Policosanol online directly right here from the VitaMonk website. We also offer it for sale sell on Amazon. You can safely purchase online from us using all major credit cards, Paypal, and Bitcoin. 

What are the shipping costs?

Well we offer free shipping on orders of $35 or more.

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