Pregnenolone

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  • Pregnenolone is an essential prohormone that’s found naturally in our bodies. It’s a natural precursor to many vital hormones and neurosteroids (like DHEA - dehydroepiandrosterone) in our bodies that we need to function properly, stay healthy and perform at our peaks.

    Taking Pregnenolone regularly can help you:

    • Support healthy hormone levels
    • Promote healthy cognitive brain function
    • Improve wakefulness
    • Improve your mood
    • Provide quality sleep
     

    Declining levels of pregnenolone could leave your brain cells increasingly vulnerable to damage - with many potential negative consequences for your health and wellbeing.

    Taking Pregnenolone supplements provides you with a potential solution to maintain healthy levels of this vital chemical and protect your brain from certain types of damage.

     

    Activate Your Dopamine Receptors

    Scientific studies have suggested that Pregnenolone may activate your dopamine receptors.

    Dopamine in a neurotransmitter that performs several vital functions for your health and wellbeing:

    • Known as your brain’s “happiness chemical”, it’s closely linked to improving your mood and increasing your happiness.
    • Studies involving increased levels of dopamine have observed an increase in feelings of wakefulness.
    • This can lead to more time spent in the crucial “slow wave” deep sleep stage - leading to more energy, a better mood and better cognition in healthy individuals.
      •  

    Could Support Improved Cognition

    Scientists have proposed that levels of neurosteroids such as pregnenolone could serve as biological “markers” of cognitive aging.

    Some human studies have also shown a correlation between neurosteroid levels, especially DHEA (which Pregnenolone leads to), and cognitive function.

    Moral of the story: if your natural pregnenolone levels go down, so could your cognitive brain function, learning and memory. 

         

    Natural, Safe, and Effective

    Vitamonk's products are manufactured in the USA and formulated by licensed doctors, while following strict GMP compliance standards. 

    We go to great lengths to make sure our supplements are 100% safe. When you use our supplements, you KNOW that you’ll only get the highest quality , all-natural ingredients (with no harmful fillers). They’re backed by science, and proven to get you results.

         

    We Guarantee Results Or Your Money Back

    We are so confident that you'll love our product, that it comes with a 100% money back guarantee.

    If for ANY reason you aren’t satisfied with this supplement after taking it (or you don’t notice results), just let us know.  

    You’ll get 100% of your money back! (No questions asked.) 

    *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  • Supplement Facts:

    • Serving Size: 1 Tablet
    • Servings Per Container: 100 
    • Amount Per Serving: 100mg or 25mg or 10mg (depending on bottle purchased)
    • Microcrystalline Cellulose, Magnesium Stearate, Stearic Acid, Croscarmellose Sodium, Dicalcium Phosphate

    Directions & Recommended Use:

    As a dietary supplement, take one tablet daily or as directed by your health care practitioner.

    Warning:

    NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR NURSING. Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of, breast cancer, prostate cancer, prostate enlargement, heart disease, low “good” cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. Pregnenolone may affect levels of other hormones, such as progesterone, estrogen, testosterone, and/or DHEA. Do not take this product if you have a history of seizures. Do not take this product if you have breast cancer, prostate cancer, or other hormone-sensitive diseases. KEEP OUT OF REACH OF CHILDREN.

     



    An Overview of Pregnenolone

        • Improves mood and well-being
        • Supports neuron activity
        • Supports deep sleep
        • Enhances motivation
        • Supports response to anxiety

    The endogenous steroid pregnenolone (pregn-5-en-3β-ol-20-one) acts as both a precursor and as an intermediate in steroid biosynthesis [1]. It is naturally synthesized in the body from cholesterol.

    As a neuroactive steroid (neurosteroid)[2], pregnenolone is able to interact with ligand-gated ion channels and cell surface receptors to alter neuronal excitability.

    Pregnenolone has been shown to be involved in the support of learning and memory [3], and to affect neuritic outgrowth and axon myelination in rats.

    Pregnenolone has also been shown to enhance levels of the neurosteroid allopregnanolone, which is known to have neuroprotective effects, enhance response of GABAA receptors, and to support inflammatory responses [4, 5, 6].

    Support of Healthy Cognition

    Role in Neuroprotection

    As a neuroprotective signaling molecule, the pregnenolone steroid is involved in mechanisms supporting stimulation of neuronal activity in the brain. This role in neuroprotection is mediated by the enzyme aromatase [7]. Pregnenolone is able to support the growth of neurons and plays a role in the creation of new synapses [8].

    Numerous studies have demonstrated that pregnenolone and/or pregnenolone sulfate is able to act at ligand-gated ion channel receptors. It acts a negative regulator of GABAA, kainite, and AMPA receptors, and as positive regulator NMDA receptors [8].

    In mice, studies using glycoprotein NR2 subunits demonstrated pregnenolone sulfate has different effects in different parts of the brain; these effects are dependent on the developmental stage [9]. Studies using rat brain revealed similar findings when investigating mRNAs that encode subunits of the NMDA receptor [10]. Thus pregnenolone may play an important role in supporting stabilization and destabilization of a receptor’s active state [11].

    Pregnenolone may also support cognitive function via the regulation of microtubules [8]. This helps to maintain neuron plasticity during healthy aging processes.

    Boosting Mood

    An important aspect of pregnenolone in relation to boosting mood is its role as a precursor of dehydroepiandrosterone (DHEA) syntheses in the brain. This steroid is involved in the modulation of synaptic transmission, and in dopamine receptor activation and release [12].

    In the brain, dopamine acts a neurotransmitter (acting as a signal between nerve cells). There are numerous dopamine pathways in the brain, and it is involved in motor control, hormonal release and in the support of reward-motivated behavior.

    Dopamine is important in the maintenance of mood in healthy individuals, and also plays a major role in reward, motivation, and salience [13, 14].

    Both Pregnenolone and allopregnanolone (3α,5α-tetrahydroprogesterone) has been found to support stabilization of mood in people with mental disorders [15]. It has also been reported that pregnenolone is able to support healthier irritability levels [16].

    Learning and Memory

    Both Pregnenolone and pregnenolone sulfate are able to modulate NMDA receptors in rodents [6]. They have been shown to support memory enhancement in spatial discrimination tasks in mice that lack NMDA receptors in the forebrain [17].

    This steroid has been reported to affect object recognition memory when injected into the lateral septum of rats [18]. The lateral septum is known to play a key role in the support of stress responses and emotional processes [19].

    Support of Deeper Sleep

    Steroid hormones are reported to play a key role in sleep regulation. Perhaps the most clear relationship between steroids and sleep occurs with the hormonal cycling of estrogen, where imbalances caused by the menopause, pregnancy, and menstruation may lead to sleep disorders [20]. Likewise, as pregnenolone is reported to be involved in slow wave (deep) sleep it is expected to be involved in the support of healthy sleep patterns [20]. The effects of pregnenolone on deeper sleep seems to act independently of nocturnal cortisol and growth hormone [21].

    Higher levels of pregnenolone are associated with enhancing paradoxical sleep and slow wave sleep. Pregnenolone alone can support paradoxical sleep without impacting wakefulness or deep sleep in rats [22]. However, the same research reported that higher pregnenolone dosages might actually impair wakefulness [23].

    Response to Anxiety

    People who suffer from anxiety have been reported to have lower levels of neuroactive steroids [24]. The administration of 400 mg pregnenolone supported enhanced levels of allopregnanolone. This is a modulator of the GABA(A) receptor, and it is associated with reduced activity levels in areas of the brain involved in generating negative emotions [24].

    Further Reading

        • Reddit: Pregnenolone – My profound good cognitive/physical experience effects on vision and clarity of thought. {https://www.reddit.com/r/Nootropics/comments/36jggr/pregnenolone_profound_cognitivephysical_experience/}
        • Quora:  Benefits and disadvantages of taking pregnenolone for several days or weeks at a young age. {https://www.quora.com/Is-it-safe-to-take-pregnenolone-at-a-young-age}
        • Wikipedia: An overview of pregnenolone {https://en.wikipedia.org/wiki/Pregnenolone}
        • Drugs.com: Definition of pregnenolone {https://www.drugs.com/dict/pregnenolone.html}

    Citations, Reviews of treatments, and References

        • [1] Flood et al. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from 1992. Proc Natl Acad SciUSA89:1567–1571.
        • [2]  Marx et al. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep 15;191:78-90. doi: 10.1016/j.neuroscience.2011.06.076.
        • [3] [Darnaudéry et al. 1998. The neurosteroid pregnenolone sulfate increases cortical acetylcholine release: a microdialysis study in freely moving rats. J Neurochem 71:2018–2022.
        • [4] Romeo et al. Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone. 1994, J Pharmacol Exp Ther 270:89–96
        • [5] Cheney et al. Pregnenolone sulfate antagonizes dizocilpine amnesia: role for allopregnanolone. 1995 Neuroreport 6:1697–1700.
        • [6] Marx et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. 2009 Neuropsychology pharmacology 34:1885–1903.
        • [7] Veiga et al. Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase. J Neurobiol. 2003 Sep 15;56(4):398-406.
        • [8] Mellon. Neurosteroid regulation of CNS development. Pharmacol Ther. 2007 Oct; 116(1): 107–124.
        • [9] Laurie et al. Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies. Brain Res Mol Brain Res. 1997 Nov;51(1-2):23-32.
        • [10] Monyer et al. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron. 1994 Mar;12(3):529-40.
        • [11] Malayev et al. Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids. Br J Pharmacol. 2002;135:901–909.
        • [12] Pérez-Neri et al. Modulation of neurotransmitter systems by dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanism of action and relevance to psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1118-30. doi: 10.1016/j.pnpbp.2007.12.001
        • [13] Tomasetti et al. Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions. Int J Mol Sci. 2017 Jan 12;18(1). pii: E135. doi: 10.3390/ijms18010135.
        • [14] Mitsi and Zachariou. Modulation of pain, nociception, and analgesia by the brain reward center. Neuroscience. 2016 Dec 3;338:81-92. doi: 10.1016/j.neuroscience.2016.05.017.
        • [15] Carter et al. GABAergic neuroactive steroids: a new frontier in bipolar disorders? Behav Brain Funct. 2012; 8: 61. doi:  10.1186/1744-9081-8-61
        • [16] Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder. J Autism Dev Disord. 2014 Nov; 44(11): 2971–2977. doi:  10.1007/s10803-014-2144-4
        • [17] Petit et al. Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice. Eur Neuropsychopharmacol. 2011 Feb; 21(2): 211–215. doi:  10.1016/j.euroneuro.2010.09.010
        • [18] Nanfaro et al. Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory. Pharmacol Rep. 2010 Mar-Apr;62(2):265-72.
        • [19] [E-10] Singewald et al. The Modulatory Role of the Lateral Septum on Neuroendocrine and Behavioral Stress Responses. Neuropsychopharmacology. 2011 Mar; 36(4): 793–804. doi:  10.1038/npp.2010.213
        • [20] Terán-Pérez et al. Steroid hormones and sleep regulation. Mini Rev Med Chem. 2012 Oct;12(11):1040-8.
        • [21] Steiger et al. Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. Brain Research. 1993 Jul 2;615(2):267-74.
        • [22] Dabra et al. Sleep-wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus. J Neurosci Res. 2004 Jun 1;76(5):742-7.
        • [23] Semeniuk et al. Neuroactive steroid levels in patients with generalized anxiety disorder. J Neuropsychiatry Clin Neurosci. 2001 Summer;13(3):396-8.
        • [24] Sripada et al. Allopregnanolone Elevations Following Pregnenolone Administration are Associated with Enhanced Activation of Emotion Regulation Neurocircuits. Biol Psychiatry. 2013 Jun 1; 73(11): 1045–1053. doi:  10.1016/j.biopsych.2012.12.008
        • [25] Vallee et al. Pregnenolone Can Protect the Brain from Cannabis Intoxication. Science  03 Jan 2014: Vol. 343, Issue 6166, pp. 94-98 DOI: 10.1126/science.1243985

    Frequently Asked Questions

    Where is pregnenolone produced in the body?

    It is mainly produced by the brain, the gonads (Testes/Ovaries), and in the adrenal glands. It is also produced at lower levels in the liver, skin, and the retina.

    What is a neurosteroid?

    This term is used to describe steroids that are synthesized in the brain, or are able to reach the brain via the blood.  They are able to support brain function.

    What is a nootropic?

    A nootropic is the name used for a supplement that may help support brain functions and processes such as memory, focus, cognition, mood, and general well being.

    What foods contain pregnenolone?

    Pregnenolone is synthesized from cholesterol, so including foods such as meat, eggs, and dairy products in your diet will help to increase levels naturally. However, as an excess of these foods is not ideal it is recommended that you only include them in your diet in moderation.

    Pregnenolone vs Progesterone or DHEA?

    Pregnenolone is a precursor to many other hormones; these include progesterone, androstadienol, and DHEA.

    Pregnenolone vs pregnenolone sulphate?

    Pregnenolone can be reversibly converted to pregnenolone sulfate by the enzymes Steroid sulfotransferase (steroid alcohol sulfotransferase) and Steroid sulfatase (STS).

    Why do the major pharmaceutical companies not push the sale of pregnenolone like they do with other steroidal products, such as cortisone?

    Pregnenolone could not be patented, so there was no major financial incentive for drug companies to promote its use.

    Are there any side effects?

    Most of the research work performed using pregnenolone uses a dose of 25 to 500 mg per day and have not reported any major side effects. Like with any drug or supplement if you experience any significant side effects it is best to stop taking them immediately and to obtain a medical opinion.

    Is pregnenolone fat soluble?

    Yes, it is a steroid and is therefore lipophilic (fat loving).

    Which is better pregnenolone or DHEA?

    Pregnenolone is a biologically active neurosteroid that is also a precursor of DHEA and cortisol, so in addition to being involved in their syntheses it also has its own specific role to play.

    Pregnenolone or testosterone?

    Many people say that they prefer to take Pregnenolone as they do not feel an angry life rage when they take it. These findings are not based upon scientific research, so take with a pinch of salt.

    Who needs pregnenolone?

    People looking to support healthy brain cognition processes.

    What does pregnenolone convert to?

    It acts as a precursor to over 200 different steroids. These include androgens, progestogens, mineralocorticoids, estrogens, and glucocorticoids

    Are your pregnenolone tablets suitable for vegetarians?

    Yes, our VegeCaps are very much vegetarian friendly.

    What is the dosage of VitaMonk pregnenolone?

    They come in three different dosages to suit your needs: 10 mg; 25 mg; and 100 mg. Each product container consists 100 capsules.

    How many tablets per day?

    As our product is available at different dosages, you should only need to take one tablet of your required amount per day. But as with all supplements, it is worth spending some time discussing your desired intake with your health practitioner.

    What is pregnenolone supplement made from?

    VitaMonk tablets are comprised of Pregnenolone, Microcrystalline Cellulose, Magnesium Stearate, Stearic acid, Croscarmellose sodium, and Dicalcium phosphate.

    I’ve heard that it can take the edge off weed?

    Really high levels of THC are thought to stimulate pregnenolone, this leads to a blunting of the type-1 cannabinoid receptor and inhibition of the effects of cannabis / Marijuana [25; via WebMD}. It may therefore one day prove useful as a natural treatment in the support of addictions.

    Where can I find pregnenolone to purchase online?

    It is available for sale right here on the VitaMonk site at a low price, and from our store on Amazon.

    Do you offer free shipping?

    Yes, if you buy more than $35 of our products then shipping is free.


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