Resveratrol With Pterostilbene

  • Resveratrol and Pterostilbene combine to make an incredibly effective, all-natural dietary supplement that can help you:

    • Reduce oxidative stress and inflammation
    • Promote healthy aging properties
    • Improve mitochondrial function and efficient ATP energy production
    • Promotes cellular rejuvenation
     

    This unique combination makes this supplement the best healthy aging and antioxidant supplement on the market today.

     

    Support Management of Inflammation and Oxidative Stress

    Both of these natural ingredients are extremely potent antioxidants that have been scientifically shown to:

    • Support a healthy response to free radicals, repairing DNA damage
    • Provide anti-inflammatory agents to promote proper inflammatory health
     

    This support of reduced oxidative stress and augmentation of inflammatory response are believed to be major contributors to supporting a healthy and long life.

     

    Promotes Healthy-Aging Properties

    Resveratrol and Pterostilbene are widely believed to support key healthy aging functions. They do that by promoting ATP production (your cell’s energy source), and a healthy mitochondria energy function.

    They do this through activating AMPK,  a protein that stimulates SIRT1 - referred to as ”the human anti-aging gene

    The promoted expression of this special gene may support longevity, healthy aging, weight loss, skin health and more.

     

    Natural, Safe, and Effective

    Vitamonk's products are manufactured in the USA and formulated by licensed doctors, while following strict GMP compliance standards. 

    We go to great lengths to make sure our supplements are 100% safe. When you use our supplements, you KNOW that you’ll only get the highest quality , all-natural ingredients (with no harmful fillers). They’re backed by science, and proven to get you results.

     

    We Guarantee Results Or Your Money Back

    We are so confident that this supplement can help you slow the negative effects of aging and support DNA maintenance, that it comes with a 100% money back guarantee.

    Try it now with NO RISK. If for ANY reason you’re not completely satisfied with this supplement after using it, just let us know.  

    You’ll get 100% of your money back! (No questions asked.) 

    *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

  • Directions & Recommended Use:

    As a dietary supplement, take one to two capsules daily or as directed by your health care practitioner.

    Warning:

    Keep out of reach of children.  Do not use if pregnant, nursing, or under the age of 18.  Consult with a heath care professional if you have or suspect a medical condition, or before beginning any new dietary supplement.  If you experience any adverse reactions please discontinue use and contact your heath care professional.

     



    Resveratrol With Pterostilbene

    Resveratrol and pterostilbene supplements are often taken for their supposed brain boosting benefits, but they are also associated with improved energy endurance, promoting a healthy inflammatory response, support of healthy blood glucose levels, and promoting healthy aging and youthfulness, supporting  against DNA damage and cell damage, weight-control, and with having cardiovascular benefits.

    Pterostilbene is chemically related to resveratrol. They differing only at their methoxy and hydroxy groups. Although they are both powerful antioxidants it is thought that their benefits relating to healthy aging are due to other mechanisms.

    Of the two molecules, the vast majority of lab research has been performed on resveratrol, largely because it is a key component of wine. It is able to indirectly activate sirtuins messengers[1], which are themselves induced during fasting and are associated with longevity. It has also been shown to have positive effects in the support of healthy blood flow, inflammation, insulin sensitivity, and of the heart.

    More recently, many researchers have focused their effects on understanding pterostilbene, which itself is a derivative of resveratrol, but has better absorption levels and greater antioxidant potency; it has been linked to promoting healthy cognition and supporting healthy glucose and cholesterol levels.

    There is presently much more known about how resveratrol works, so although the supplement has already been shown to have many desirable aspects it is more usual to take resveratrol with pterostilbene in the world of nootropics.

    A Look at Resveratrol

    The stilbenoid resveratrol (3,5,4′-trihydroxy-trans-stilbene) is naturally found in grapes, and its presence as one of the key antioxidative components of wine has made it of great interest. For those of you who may not know, wine is strongly associated with good health in France and Spain, and is thought to be one of the main reasons why the French people generally have a healthy heart despite consuming a rich diet (the French Paradox). It is a natural phenol phytoalexin acting to protect grapes from infection by the necrotrophic fungus Botrytis cinerea.

    Because of its presence in wine, the compound is often referred to as red wine extract, but in addition to wines it is also found in blueberries, mulberries, lingonberries/partridgeberries, raspberries, and in plants belonging to the Senna genus[2].

    Key Positive Effects of Resveratrol

    Supporting Healthy Blood Flow

    General Blood Flow has been shown to increase at low dosages of resveratrol [3] and cerebral blood flow (with no associated mental fatigue) and oxygen at larger doses[4].

    With regards to general cardioprotective effects, prolonged supplementation with 10 mg resveratrol has been shown to lead to support healthy endothelial function, left ventricular diastolic function, and levels of LDL-cholesterol[3].

    Trans-resveratrol administered orally as single doses of 250 mg and 500 mg was found to support cerebral blood flow and hemodynamics (differences in oxygenation of hemoglobin) after 45 minutes of absorption in a dose dependent manner. These randomized trials were performed on 22 healthy human beings given cognitive tasks to perform that affected the frontal cortex[4].

    Blood Glucose and Blood Pressure

    In trials performed in obese men over a 30 day period designed to look at the calorie restriction effects of supplementation with resveratrol, it was found that it supported healthy blood pressure and blood glucose levels under a daily supplementation of 150 mg resveratrol[5].

    In addition to the beneficial blood aspects, the authors also reported that daily supplementation supported healthy resting metabolic rates and a more restful sleep, induced the activity of citrate synthase in the mitochondria, and activated PGC-1α, AMPK, and SIRT1 proteins. They concluded that the daily supplementation had similar biological effects to that of calorie restriction.

    Support of Healthy Insulin levels and Insulin Sensitivity

    A small trial conducted in 2011 showed resveratrol was able to support healthy insulin and glucose levels in obese people[6, 7].

    Furthermore, inhibition of adipogenic differentiation and preadipocyte proliferation occurs in a Sirt1 dependent manner. The authors put forward that the induction of intracellular pathways by resveratrol may one day act as a target in the treatment of obesity related endocrine and metabolic effects.

    Fighting Acne

    When applied topically to the face, resveratrol cream was shown to support against acne[8]. There was also a significant reduction in lesions.

    Enhancement of Melatonin Neuroprotective Effects

    The hormone Melatonin is involved in circadian rhythm entrainment and therefore plays a major role in the timing of the sleep-wake pattern, seasonal reproduction, and blood pressure regulation. Melatonin is able to enhance the induction of Heme-Oxygenase 1 by resveratrol in neurons[9].

    The synergy between the two does not increase mRNA levels, but does inhibit the ubiquitin-proteasome pathway. Furthermore, this synergy between these two components leads to enhancements of anti-oxidative properties and neuroprotection effects.

    Neurology and Cognition

    As mentioned above, resveratrol can cross the blood-brain barrier and is able to support the human cerebral blood flow[4]. It is also thought to suppress the release of glutamate in the neurons, thus playing a role in the control of glutaminergic signaling[10].

    Some of the neuroprotective effects linked with resveratrol includes overcoming excitotoxicity effects (such as ammonia activated by oxidative stress and nitric oxide production)[11] in morphine tolerant mice through suppression of PSD-95 expression[12].

    Healthy Aging

    Most of the research into healthy aging has been performed in the model species Drosophilia and C.Elegans.

    There is a body of evidence that resveratrol supports healthy aging in these organisms through up-regulation of Juvenile Hormone. It should be noted that this exact hormone is not present in mammals. So any healthy aging effects associated with resveratrol are resultant from another mechanism(s).

    In mammals, resveratrol has been shown to support many noticeable effects related to aging such as cognition, bone mass, and muscle mass as one ages[13].

    Cardiovascular Health

    As resveratrol is a direct free radical scavenger it is expected to be beneficial in preserving the endothelium from the impact of vasorelaxation agents such as acetylcholine and nitric oxide[14].

    It has also been shown to be beneficial for relaxation of the arteries. Hypertensive rats provided with the equivalent resveratrol supplementation as found in glasses of wine were found to have increased levels of acetylcholine-induced maximal vasorelaxation[15]

    As mentioned previously, supplementation also has health benefits on blood pressure at dosages of 150 mg[5].

    Obesity

    Due to the way that resveratrol interacts with cell cycles it is expected to have beneficial long-term effects in the fighting obesity.

    It is thought to benefit both muscle and bone health through interfering with the conversion of mesenchymal cells into adipocytes during fat metabolism, this allows stem cells to be used in much more beneficial ways, e.g, for the creation of muscle and bone cells[16].

    Resveratrol Synergism With Other Nutrients and With Hormones

    In addition to its synergy with melatonin, resveratrol has been reported as having nutrient to nutrient interactions with the flavonoid Genistein (supporting apoptosis during fat metabolism[17]), Vitamin D (bone metabolism, redirection of stem cells[18]), Quercetin (protects blood vessels[19]), curcumin,  D-Glucaro-1,4-Lactone, Indole-3-Carbinol, Grape Seed Extract, and β-1,3-Glucan.

    Resveratrol has also been shown to have effects on hormonal estrogen metabolism and on testosterone[20].

    A Look at Pterostilbene

    The powerful antioxidant pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) has a very similar structure to resveratrol but is thought to be much more bioavailable and more potent as an antioxidant.

    Some of the health benefits in which it is reported to be beneficial include support of blood glucose levels, cognition, prevention of cell damage, reducing oxidative stress, supporting healthy inflammatory response and aging, weight-loss, and enhancement of the cardiovascular system.

    It is naturally present in blueberries (the focus of many of the scientific research studies into it), grape leaves, Pterocarpus, almonds, and peanuts.

    Healthy Aging

    As people get older their cells go through a natural decline in antioxidant activity. Thus it is important to support against declines in this process as it can result in many age related conditions, such as a decline in cognition levels and impaired motor function. Pterostilbene is able to act in the mitochondria (the energy center of the cell) to alter the regulation of numerous genes involved in dealing with oxidative stress conditions [21].

    NAD+ is involved in the redox reaction in the mitochondria, and therefore plays a major role in the repair of damaged DNA and in cellular metabolism (which are all important processes in the aging process). When 50 mg of pterostilbene was used in combination with 250 mg of nicotinamide riboside (Niagen) there was a benefit in NAD+ levels in the blood[22].

    Cognition/Brain Health and Function

    There have been many neurological health benefits found to be directly related to pterostilbene, these include the control of neuroinflammation, support of response to anxiety, and improvements in mental actions through increased levels of it in the hippocampus[23]

    Cardiovascular System

    Pterostilbene is linked with supporting healthy blood pressure, activating enzymes with antioxidant roles, and supporting healthy levels of cholesterol and serum triglycerides.

    In research using hamster, there was a significant decrease in LDL (Bad cholesterol) and a slight rise in good cholesterol[24], there was also an associated weight loss observed when taken alongside grape seed extract[25].

    Inflammatory Response and Immunological Aspects

    Ingesting pterostilbene orally is reported to reduce neutrophils oxidation caused by the NADPH oxidase enzyme[26]. This enzyme naturally helps to protect against bacterial invasion but excess levels of it can lead to inflammation-associated injuries. Resveratrol is also an inhibitor of NADPH oxidase.

    Further Recommended Published Reading

    • Wikipedia: [https://en.wikipedia.org/wiki/Resveratrol]
    • Reddit: A look at Resveratrol on Examine Per Se[https://www.reddit.com/r/Fitness/comments/srwt5/resveratrol_has_been_preliminarily_completed_at/]
    • WebMD: Benefits and Side effects of an all natural treatment  [http://www.webmd.com/heart-disease/resveratrol-supplements]
    • Quora questions: What's a sensible dosage for Resveratrol? [https://www.quora.com/Whats-a-sensible-dosage-for-Resveratrol]
    • PubMed / Medscape: Mitochondrial Protection by Resveratrol [http://www.medscape.com/viewarticle/745451] 

    References, Reviews, and Citations

    [1] Poulose et al. Effects of pterostilbene and resveratrol on brain and behavior. Neurochem Int. 2015 Oct;89:227-33. doi: 10.1016/j.neuint.2015.07.017

    [2] Jasiński et al. Resveratrol in prostate diseases - a short review. Cent European J Urol. 66 (2): 144–9. doi:10.5173/ceju.2013.02.art8

    [3] Magyar et al. Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease. Clin Hemorheol Microcirc. 2012;50(3):179-87. doi: 10.3233/CH-2011-1424

    [4] Kennedy et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr. 2010 Jun;91(6):1590-7. doi: 10.3945/ajcn.2009.28641

    [5] Timmers et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011 Nov 2;14(5):612-22.

    [6] Baile et al. Effect of resveratrol on fat mobilization. Ann N Y Acad Sci. 2011 Jan;1215:40-7. doi: 10.1111/j.1749-6632.2010.05845.x.

    [7] Fischer-Posovszky et al. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. 2010 Jul;92(1):5-15. doi: 10.3945/ajcn.2009.28435.

    [8] Fabbrocini et al. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin Dermatol. 2011 Apr 1;12(2):133-41. doi: 10.2165

    [9] Orallo et al. The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol Pharmacol. 2002 Feb;61(2):294-302.

    [10] Friedman et al. Lack of resveratrol neuroprotection in developing rats treated with kainic acid. Neuroscience. 2013 Jan 29;230:39-49. doi: 10.1016/j.neuroscience.2012.10.063.

    [11] Bobermin et al. Resveratrol prevents ammonia toxicity in astroglial cells. PLoS One. 2012;7(12):e52164. doi: 10.1371/journal.pone.0052164

    [12] Leite et al. Ammonia-induced alteration in S100B secretion in astrocytes is not reverted by creatine addition. Brain Res Bull. 2006 Jun 30;70(2):179-85

    [13] Jannin et al. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem Pharmacol. 2004 Sep 15;68(6):1113-8.

    [14] Ku et al. Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase. Endocr J. 2012;59(2):103-9.

    [15] Minakawa et al. Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells. J Clin Biochem Nutr. 2011 May;48(3):237-44. doi: 10.3164/jcbn.10-119

    [16] Park et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012 Feb 3;148(3):421-33. doi: 10.1016/j.cell.2012.01.017

    [17] Vetvicka et al. Glucan and resveratrol complex--possible synergistic effects on immune system. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Jun;151(1):41-6.

    [18] Ferraz da Costa et al. Transient Transfection of a Wild-Type p53 Gene Triggers Resveratrol-Induced Apoptosis in Cancer Cells. PLoS One. 2012;7(11):e48746. doi: 10.1371/journal.pone.0048746.

    [19] Hope er al. Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S52-61. doi: 10.1002/mnfr.200700448.

    [20] Gao et al. Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J Nutr. 2002 Jul;132(7):2076-81.

    [21] Joseph. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J Agric Food Chem. 2008 Nov 26;56(22):10544-51. doi: 10.1021/jf802279h.

    [22] ELYSIUM HEALTH Press Release: [https://www.elysiumhealth.com/clinical-trial-press-release]

    [23] Al Rahim et al. Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation. Planta Med. 2013 Jun;79(9):723-30. doi: 10.1055/s-0032-1328553 ad.

    [24] Rimando et al. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem. 2005 May 4;53(9):3403-7

    [25] Riche et al. Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. Evid Based Complement Alternat Med. 2014;2014:459165. doi: 10.1155/2014/459165 vs

    [26] Jancinová et al. The combined luminol/isoluminol chemiluminescence method for differentiating between extracellular and intracellular oxidant production by neutrophils. Redox Rep. 2006;11(3):110-6.

    Common Questions (FAQs)

    Would I be better taking Resveratrol or just drinking more wine?

    Other than the massive risk of the hangover that you are going to get when consuming large amounts of French and Spanish red wine, much of the research work carried out has involved supplementations with greater amounts of resveratrol than are present in wine (about 40–100 bottles worth!). That said many of the benefits associated with blood flow were recorded at low levels ~10 mg resveratrol and help to explain why consumption of antioxidant rich wine may help to maintain a strong heart. As with many natural treatments, moderation is key.

    Do I have to take Resveratrol with Pterostilbene?

    No, VitaMonk also sells a pterostilbene supplement in capsules as a separate product.

    Does resveratrol keep cells from aging?

    Most of the healthy aging effects associated with resveratrol reported by researchers was carried out in insects and worms, and seems to affect a hormone that is not found in humans. However, supplementation has been reported to have a positive effect on various aspects associated with aging such as muscle tissue loss, cognition, and bone health.

    What about combining Pterostilbene with Nicotinamine Riboside (nr)?

    Niagen nicotinamide riboside with pterostilbene

    Niagen® or Nicotinamine riboside is a precursor of NAD+. It is a form of vitamins B3. Some of the research results mentioned above made use of pterostilbene with Nicotinamine riboside. This supplement product is also available from VitaMonk, for sale online here on the site or from our Amazon site store.

    Does this product relieve other things? If it does, then how?

    This antioxidant supplement is associated with many health benefits such as heart health, healthy aging, and cognition. It is not a cure all designed to treat all conditions

    What foods containing Pterostilbene and Resveratrol can I include in my diet?

    They are present in multiple foods at fairly low levels such as grapes, blueberries, almonds, and peanuts, and also add in the drink red wine.

    Where can I buy it on sale near me?

    You can purchase the best resveratrol and pterostilbene right here from VitaMonk: the top supplement store online.

    How many capsules are there in a container?

    60 capsules

    Quick Questions

    Is resveratrol a polyphenol? Yes

    How much resveratrol is in a glass of wine? ~ 2 mg (~12.6 mg in a liter of red wine)

    Is resveratrol an estrogen?

    No, but it does support healthy estrogen levels.

    Pterostilbene with Nicotinamine?

    Easy to take them combined using our specific product.

    What is the recommended resveratrol Dosage?

    It is not an essential nutrient, so there is no recommended RDA. A lot of the research work uses amounts of 500 mg to support cognitive benefits, but as little as 10 mg has been shown to support more effective general (not brain) blood flow.

    Resveratrol for acne?

    It is used topically as a cream.

    Does it offer pain relief?

    No, it is not used to relieve pain; it is not one of the known remedies for this condition.

    Can it restore and boost lower hormone levels for men and for women?

    Although it does impact estrogen levels, this is not the primary purpose of this supplementation.

    Which foods have resveratrol?

    Wine, almonds, nuts.

    Which resveratrol brand is best?

    VitaMonk, of course!

    What does each tablet/pill contain?

    Capsules contain the following ingredients:

    • Trans-Resveratrol, (standardized to 50%) 600 mg (Polygonum Cuspidatum)
    • Trans-Pterostilbene, 60 mg
    • Vegetable cellulose (capsule) and rice flour

    How much to take?

    For maximal health benefits it is recommended to take the product daily.

    Are VitaMonk nutrition supplement, tablets, powders, and pills suitable for seniors and vegetarians?

    Yes, we produce gluten free herb vegicaps that are suitable for vegetarians; they are not tested on animals.

    Where is the Pterostilbene with Resveratrol product produced?

    Our products are made in the USA. Compare this with other manufacturers.

    What are the shipping costs?

    Free shipping makes our already cheap goods even more affordable and is available on all orders of $35 or more.


    Related Items