Nicotinamide Mononucleotide Made Easy: How to Understand The Latest Anti-Aging Breakthrough

Reverse aging?

It's not as crazy as you may think.

You're about to discover all about a molecule called nicotinamide mononucleotide, or NMN for short, that has been pouring through the headlines of scientific journals and clinical studies lately.

It has engineers and scientists rushing to become the name behind one of the biggest anti aging updates of the past decade. Nicotinamide mononucleotide has quickly moved from experiments on yeast and rodents... to it's upcoming debut of their first human clinical trials in Tokyo, Japan.

Nicotinamide Mononucleotide

The hype is real.  

And we took it upon ourselves to break down exactly what this nicotinamide mononucleotide "discovery" is, and how it can be easily understood.

Researchers are saying nicotinamide mononucleotide might just be the missing key to regenerating healthy cells through “old” age, allowing your youthful existence to be sustained for much longer. They're speculating our life expectancy to be extended by an additional 50 years... while feeling much more energetic and much healthier in appearance. They have found what they believe to be the underlying CAUSE of aging... and not just the side effects.

“Our results unveil a key mechanism in cellular degeneration and aging, but beyond that they point to a therapeutic avenue to halt and reverse age-related and radiation-induced DNA damage,” said senior author David Sinclair, a professor in the Department of Genetics at HMS, co-director of the Paul F. Glenn Center for the Biology of Aging, and professor at the University of New South Wales School of Medicine in Sydney. 

Imagine aging like a dial being turned...

Instead of your body producing the healthy cells like our teenage years... the needle moves and instead the cells grow weaker, and slower in performance. 

Health is supposed to be a never ending process, but soon it does. 

Now, what keeps you healthy might not have to end.

Aging is being realized as a "lack" of a certain compound being produced within the body. Our NAD+ levels declines as we age—by 50, levels are half of what they were at age 20.

It is being speculated that we can simply "supplement" this molecule. From there, our body will turn it into what is called NAD+. We will explain this later.

Just know, that supplementing NMN to produce NAD+ is like a bodybuilder taking protein to rebuild their muscles. Your body producing NAD+ is like a roofer replacing worn panels on an aged roof. Being able to produce NAD+ is like a pool cleaner, coming in and re-balancing the chemicals in your pool.  

Scientists are pinning down exactly what is causing "aging". And it's one molecule that looks to be the culprit. Rather, a "lack OF" this molecule.  

“The aging process we discovered is like a married couple—when they are young, they communicate well, but over time, living in close quarters for many years, communication breaks down,” said Harvard Medical School Professor of Genetics David Sinclair, senior author on the study. “And just like with a couple, restoring communication solved the problem.” 

Once you see how scientists are saying how simple it can be to replace this "lack" of molecule...

You may be able to begin to reverse the complications that happen with aging, and improper cell function. Everything is entirely speculative at this point. These teams of researchers are racing to be the first to prove just how this molecule will change life as we know it.  

They're hoping that it can be used to reverse chronic illnesses and cancers that develop at an early age. What's more, they're eager to get this molecule into proper channels to guard against any injuries and dysfunctions that form later in life, for whatever reason they occur.

But this is nothing “new”. 

We have known about this little molecule for over a century... technology didn't allow us to capitalize our health on its potential — until now. And this is may be the most legitimate, most exciting health research finding of the decade.

Millions of research dollars are pointing to the capability of restoring our body's ability to produce healthy cells — instead of weaker, age-worn cells. 

And you may not believe it’s possible, but NMN is actually right now available to be purchased for personal use if you know where to find it.If this hasn't gotten you excited yet, then your energy might be low and you definitely need some!  

If you want to be one of the first to get your hands on this. Keep reading.

Nicotinamide Mononucleotide (NMN)

Now that I've got you excited... 

Let's walk through "what" this molecule really is.

We've combed through dozens of scientific journals, crunched through the clinical studies and maxed out our coffee maker to break down everything you need to know. Right here, in one simple, easy to understand article at Vitamonk. 

We made it easy for you to understand why it works, and why it's different from anything else. Most importantly, we'll explore how you can get your hands on this molecule from natural sources, including those found right at your local grocery store.  

All this will happen for you within the next 5-10 minutes it takes you to read the rest of this article. So put down your phone, turn off any distractions and let's see how you can best get this molecule into your hands. After that, what you choose to do with this information is entirely up to you.

Nicotinamide Mononucleotide Clinical Studies Are Showing Huge Potential in Support of The First "Anti-Aging" Pill

Consider this excerpt of Dr. David Sinclairs findings...

"Examining muscle from two-year-old mice that had been given the NAD-producing compound for just one week, the researchers looked for indicators of insulin resistance, inflammation and muscle wasting. In all three instances, tissue from the mice resembled that of six-month-old mice. In human years, this would be like a 60-year-old converting to a 20-year-old in these specific areas." (1) https://hms.harvard.edu/news/genetics/new-reversible-cause-aging-12-19-13 

This was from one of just several experiments done on mice. What's most interesting to know is that this not a year-long study. In fact.. it was done on a much shorter timespan.

 

Here is another excerpt on the study that was published through the Harvard Gazette.

"After receiving NMN with their drinking water for a week, however, old mice showed marked differences both in NAD levels and PARP1 activity. NAD levels in the livers of old mice shot up to levels similar to those seen in younger mice." (2) https://news.harvard.edu/gazette/story/2017/03/harvard-scientists-pinpoint-critical-step-in-dna-repair-cellular-aging/

Of course, mice have a much different biology structure than we do. However, this is a very large step forward to being able to replicate the results in humans.

Additional clinical Studies on NMN are already undergoing process in places like Tokyo, Japan through independent research teams hoping to claim the achievement.

First, what is NMN?

In its most simplistic definition... 

Nicotinamide mononucleotide, known short-hand as NMN, is a derivative of Vitamin B3. Research has determined this compound influences our body's use of energy. 

NMN is what is called a "precursor" to a compound called nicotinamide adenine dinucleotide, known shorthand as NAD+. NAD+ is what is making headlines all around the world, but NMN is responsible for creating it.

“NAD+ is the closest we’ve gotten to a fountain of youth,” says David Sinclair. “It’s one of the most important molecules for life to exist, and without it, you’re dead in 30 seconds.”

Here's how Nicotinamide mononucleotide works...

Deep inside our cells, hundreds of little processes are happening.

There are many major processes going on within the cells of our body. As you know, each cell has a function. These assigned cells all have their own identical processes and are clones of each other.  

This gives each cell their function. Each individual cell follows an identical process as the cell next to to it. When the cell is no longer able to continue this process, is when the cell begins to fade out and is quickly replaced.

Your body has a "recipe" for creating and organizing these intra-cellular processes. What happens is as we age, our body somewhere along the way loses its ability to correctly "follow the recipe".

Therefore, your body no longer produces healthy, optimal functioning cells... and instead your cells are weaker, they do not last as long, and create problematic conditions. This can be accelerated due to poor diet, lack of exercise, stress... there are many factors.

What NMN does is maintain your cells ability to "follow the recipe" to continue to produce healthy cells, maintaining your best health within any condition. Your body can only use and work within what you provide. 

It works because NMN is what's called a "precursor" to NAD+. Inside your body is an enzyme that converts NMN into NAD+. It's this that is what keeps your cells on track, and following "the recipe". 

Essentially, our levels of NAD+ drop as we age. This results in our body producing far less energy than it used to. The communication within the cells breaks down.

This results in noticeable physical fatigue and a lack of interest towards what used to get us excited. Now, we simply don't have the energy for it.  

By increasing your intake of NMN, research has found a very positive effect on energy levels in current studies.

NMN and Vitamin B3

There are many sources of NMN that can be found right at your local grocery. Just look for foods that are rich in Vitamin B3.

Possibly those with the highest risk of a vitamin B3 Niacin deficiency are those who consume mostly a diet of processed foods. Sugary foods, processed grains, white bread, white flour, wheat products and corn syrup can cause inadequate Niacin levels. 

Vegetarians will enjoy several dietary sources of NMN. Mushrooms, green peas, potatoes, almonds and sunflower seeds. Fruits like peaches and grapefruit are great dietary sources of NMN as well.

These also include poultry and white meats like pork. One of the richest sources of NMN is within fresh fish which is high in Niacin like swordfish, tuna and salmon. But it's important to make sure that you're always choosing natural, organic sources.  

For example, you will want to avoid farm-raised salmon. Instead, look for wild caught salmon from Alaska. It's unfortunate that much of today's food is grown with pesticides, synthetic hormones and is genetically modified so they have much less nutrient density.

It's important to avoid heavily processed foods. Sugary foods, processed grains, white bread, white flour, wheat products and corn syrup can cause inadequate Niacin levels.

More, you can also supplement NMN, Dr. David Sinclair takes 500mg daily, which is often two tablets every morning. This is a much easier process because the amount of food that you would need to eat to get this dosage would be substantial, and virtually impossible.  

You now know all you need to know about nicotinamide mononucleotide 

Now you should have a clear understanding in simple terms how this molecule plays such an important role within the body. The research is still being done, but right now, you can enjoy the benefits of supplementing NMN in it's safe and current form.

The ongoing research into the anti aging effects is extremely exciting for anyone who wants to live a healthier and longer life. Although there is still much more research to be done before we create the immortality drug, a future where this exists is coming.

Make sure to check back. We are looking forward to updating this article with the results of the clinical trials on humans debuting soon this year, when the results will be published.

Sources

  • https://www.ncbi.nlm.nih.gov/pubmed/26343585
  • https://hms.harvard.edu/news/genetics/new-reversible-cause-aging-12-19-13
  • https://www.ncbi.nlm.nih.gov/pubmed/29634344
  • http://time.com/5159879/is-an-anti-aging-pill-on-the-horizon/
  • https://www.nature.com/articles/s41598-017-14866-z
  • https://news.harvard.edu/gazette/story/2017/03/harvard-scientists-pinpoint-critical-step-in-dna-repair-cellular-aging/
  • https://hms.harvard.edu/news/rewinding-clock
  • https://hms.harvard.edu/news/genetics/new-reversible-cause-aging-12-19-13
  • http://www.cell.com/cell/fulltext/S0092-8674(13)01521-3 
  • Majority of the research synthesized from the first pub med link:
  • https://www.ncbi.nlm.nih.gov/pubmed/26343585 Preyat Nicolas, Leo Oberdan.Complex role of nicotinamide adenine dinucleotide in the regulation of programmed cell death pathways. Biochemical Pharmacology
  •  

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